Hidden rheumatoid factor and Wa idiotype expression in juvenile rheumatoid arthritis

Norman Todd Ilowite, J. F. Wedgwood, T. L. Moore, T. Ramakrishnan, V. R. Bonagura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The major rheumatoid factor cross-reactive idiotype, which was defined by prototypic monoclonal IgM rheumatoid factors from Waldenstrom's macroglobulinaemia patient Wa, is present on 60% of all monoclonal IgM RF paraproteins. One-third of patients with juvenile rheumatoid arthritis (JRA), who are seronegative for classic IgM rheumatoid factor (RF), express the Wa idiotype in high titre in their sera. To determine if the Wa idiotype is present on hidden rheumatoid factors in JRA patient sera, we studied hidden RF expression by both ELISA and haemolytic assay techniques. The majority of JRA sera with increased concentrations of the Wa idiotype did not have increased RF activity nor hidden RF activity. In some JRA patients, the Wa idiotype may be expressed on a parallel set of immunoglobulin molecules, related to RFs, but lacking the ability to bind to IgG.

Original languageEnglish (US)
Pages (from-to)453-460
Number of pages8
JournalScandinavian Journal of Immunology
Volume34
Issue number4
StatePublished - 1991

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Juvenile Arthritis
Rheumatoid Factor
Immunoglobulin M
Serum
Paraproteins
Waldenstrom Macroglobulinemia
Immunoglobulins
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Immunology

Cite this

Ilowite, N. T., Wedgwood, J. F., Moore, T. L., Ramakrishnan, T., & Bonagura, V. R. (1991). Hidden rheumatoid factor and Wa idiotype expression in juvenile rheumatoid arthritis. Scandinavian Journal of Immunology, 34(4), 453-460.

Hidden rheumatoid factor and Wa idiotype expression in juvenile rheumatoid arthritis. / Ilowite, Norman Todd; Wedgwood, J. F.; Moore, T. L.; Ramakrishnan, T.; Bonagura, V. R.

In: Scandinavian Journal of Immunology, Vol. 34, No. 4, 1991, p. 453-460.

Research output: Contribution to journalArticle

Ilowite, NT, Wedgwood, JF, Moore, TL, Ramakrishnan, T & Bonagura, VR 1991, 'Hidden rheumatoid factor and Wa idiotype expression in juvenile rheumatoid arthritis', Scandinavian Journal of Immunology, vol. 34, no. 4, pp. 453-460.
Ilowite, Norman Todd ; Wedgwood, J. F. ; Moore, T. L. ; Ramakrishnan, T. ; Bonagura, V. R. / Hidden rheumatoid factor and Wa idiotype expression in juvenile rheumatoid arthritis. In: Scandinavian Journal of Immunology. 1991 ; Vol. 34, No. 4. pp. 453-460.
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