HHV-8 and AIDS-related CNS lymphoma

Susan Morgello, Michele Tagliati, Michelle R. Ewart

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Human herpesvirus 8 (HHV-8), the Kaposi's sarcoma (KS)-associated herpesvirus, is closely related to the transforming Epstein-Barr virus (EBV) and may be detected in AIDS-related, EBV-containing, body-cavity-based lymphomas. Accordingly, we analyzed 27 EBV-positive, AIDS-related CNS lymphomas for HHV-8 sequences. Only one tumor yielded HHV-8 sequences; this tumor arose in a patient with concomitant systemic lymphoma and a history of KS. We conclude that HHV-8 is unlikely to have a major role in the pathogenesis of AIDS-related, EBV-associated CNS lymphomas.

Original languageEnglish (US)
Pages (from-to)1333-1335
Number of pages3
JournalNeurology
Volume48
Issue number5
DOIs
StatePublished - May 1997
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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