Heterosynaptic LTD of hippocampal GABAergic synapses

A novel role of endocannabinoids in regulating excitability

Vivien Chevaleyre, Pablo E. Castillo

Research output: Contribution to journalArticle

471 Citations (Scopus)

Abstract

Neuronal excitability and long-term synaptic plasticity at excitatory synapses are critically dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy should have great impact on neuronal function and neural network processing. We describe here a form of activity-dependent long-term depression at hippocampal inhibitory synapses that is triggered postsynaptically via glutamate receptor activation but is expressed presynaptically. That is, glutamate released by repetitive activation of Schaffer collaterals activates group I metabotropic glutamate receptors at CA1 pyramidal cells, triggering a persistent reduction of GABA release that is mediated by endocannabinoids. This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory.

Original languageEnglish (US)
Pages (from-to)461-472
Number of pages12
JournalNeuron
Volume38
Issue number3
DOIs
StatePublished - May 8 2003

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Endocannabinoids
Synapses
Pyramidal Cells
Metabotropic Glutamate Receptors
Neuronal Plasticity
Cannabinoids
Long-Term Potentiation
Glutamate Receptors
gamma-Aminobutyric Acid
Glutamic Acid
Hippocampus
Learning
Depression

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Heterosynaptic LTD of hippocampal GABAergic synapses : A novel role of endocannabinoids in regulating excitability. / Chevaleyre, Vivien; Castillo, Pablo E.

In: Neuron, Vol. 38, No. 3, 08.05.2003, p. 461-472.

Research output: Contribution to journalArticle

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