Abstract
Neuronal excitability and long-term synaptic plasticity at excitatory synapses are critically dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy should have great impact on neuronal function and neural network processing. We describe here a form of activity-dependent long-term depression at hippocampal inhibitory synapses that is triggered postsynaptically via glutamate receptor activation but is expressed presynaptically. That is, glutamate released by repetitive activation of Schaffer collaterals activates group I metabotropic glutamate receptors at CA1 pyramidal cells, triggering a persistent reduction of GABA release that is mediated by endocannabinoids. This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 461-472 |
| Number of pages | 12 |
| Journal | Neuron |
| Volume | 38 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 8 2003 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Heterosynaptic LTD of hippocampal GABAergic synapses : A novel role of endocannabinoids in regulating excitability. / Chevaleyre, Vivien; Castillo, Pablo E.
In: Neuron, Vol. 38, No. 3, 08.05.2003, p. 461-472.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heterosynaptic LTD of hippocampal GABAergic synapses
T2 - A novel role of endocannabinoids in regulating excitability
AU - Chevaleyre, Vivien
AU - Castillo, Pablo E.
PY - 2003/5/8
Y1 - 2003/5/8
N2 - Neuronal excitability and long-term synaptic plasticity at excitatory synapses are critically dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy should have great impact on neuronal function and neural network processing. We describe here a form of activity-dependent long-term depression at hippocampal inhibitory synapses that is triggered postsynaptically via glutamate receptor activation but is expressed presynaptically. That is, glutamate released by repetitive activation of Schaffer collaterals activates group I metabotropic glutamate receptors at CA1 pyramidal cells, triggering a persistent reduction of GABA release that is mediated by endocannabinoids. This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory.
AB - Neuronal excitability and long-term synaptic plasticity at excitatory synapses are critically dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy should have great impact on neuronal function and neural network processing. We describe here a form of activity-dependent long-term depression at hippocampal inhibitory synapses that is triggered postsynaptically via glutamate receptor activation but is expressed presynaptically. That is, glutamate released by repetitive activation of Schaffer collaterals activates group I metabotropic glutamate receptors at CA1 pyramidal cells, triggering a persistent reduction of GABA release that is mediated by endocannabinoids. This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory.
UR - http://www.scopus.com/inward/record.url?scp=0037986346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037986346&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(03)00235-6
DO - 10.1016/S0896-6273(03)00235-6
M3 - Article
VL - 38
SP - 461
EP - 472
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 3
ER -