Herpes zoster in women with and at risk for HIV: Data from the women's interagency HIV study

Marshall J. Glesby, Donald R. Hoover, Tianren Tan, Qiuhu Shi, Wei Gao, Audrey L. French, Toby Maurer, Mary Young, Jack DeHovitz, Jenny Ru, Kathryn Anastos

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Herpes zoster occurs at all CD4 cell counts in HIV-infected adults. It was hypothesized that even in the era of highly active antiretroviral therapy (HAART), zoster risk is higher in HIV-infected than uninfected women. Methods: Generalized estimating equations modeled self-reported occurrence of zoster between semiannual visits among 1832 HIV-infected and 489 HIV-uninfected women in the Women's Interagency HIV Study followed for up to 7.5 years. Results: A total of 337 (18.4%) HIV-infected and 7 (1.4%) HIV-uninfected women reported zoster at some time during follow-up. Using HIV-infected women with CD4 >750 cells/μL as the reference category, the odds ratios for reporting zoster since the prior visit were: 1.43 (95% CI 0.86-2.37) for CD4 500-749 cells/μL, 2.07 (95% CI 1.27-3.38) for CD4 350-499 cells/μL, 2.72 (95% CI 1.66-4.46) for CD4 200-349 cells/μL, and 3.16 (95% CI 1.92-5.18) for CD4 <200 cells/μL, compared with 0.11 (95% CI 0.046-0.26) for HIV-uninfected women. In multivariate analyses using visits from all HIV-infected women and only those who initiated HAART, lower CD4 cell count was more strongly associated with zoster incidence than were other clinical indicators. Conclusions: Herpes zoster is associated with degree of immunosuppression in HIV-infected women, but even women with high CD4 counts are at greater risk of zoster than HIV-uninfected women.

Original languageEnglish (US)
Pages (from-to)1604-1609
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume37
Issue number5
DOIs
StatePublished - Dec 15 2004

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Herpes Zoster
HIV
CD4 Lymphocyte Count
Highly Active Antiretroviral Therapy
Immunosuppression
Multivariate Analysis
Odds Ratio

Keywords

  • Epidemiology
  • Herpes zoster
  • HIV infection
  • Women

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Herpes zoster in women with and at risk for HIV : Data from the women's interagency HIV study. / Glesby, Marshall J.; Hoover, Donald R.; Tan, Tianren; Shi, Qiuhu; Gao, Wei; French, Audrey L.; Maurer, Toby; Young, Mary; DeHovitz, Jack; Ru, Jenny; Anastos, Kathryn.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 37, No. 5, 15.12.2004, p. 1604-1609.

Research output: Contribution to journalArticle

Glesby, MJ, Hoover, DR, Tan, T, Shi, Q, Gao, W, French, AL, Maurer, T, Young, M, DeHovitz, J, Ru, J & Anastos, K 2004, 'Herpes zoster in women with and at risk for HIV: Data from the women's interagency HIV study', Journal of Acquired Immune Deficiency Syndromes, vol. 37, no. 5, pp. 1604-1609. https://doi.org/10.1097/00126334-200412150-00013
Glesby, Marshall J. ; Hoover, Donald R. ; Tan, Tianren ; Shi, Qiuhu ; Gao, Wei ; French, Audrey L. ; Maurer, Toby ; Young, Mary ; DeHovitz, Jack ; Ru, Jenny ; Anastos, Kathryn. / Herpes zoster in women with and at risk for HIV : Data from the women's interagency HIV study. In: Journal of Acquired Immune Deficiency Syndromes. 2004 ; Vol. 37, No. 5. pp. 1604-1609.
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abstract = "Background: Herpes zoster occurs at all CD4 cell counts in HIV-infected adults. It was hypothesized that even in the era of highly active antiretroviral therapy (HAART), zoster risk is higher in HIV-infected than uninfected women. Methods: Generalized estimating equations modeled self-reported occurrence of zoster between semiannual visits among 1832 HIV-infected and 489 HIV-uninfected women in the Women's Interagency HIV Study followed for up to 7.5 years. Results: A total of 337 (18.4{\%}) HIV-infected and 7 (1.4{\%}) HIV-uninfected women reported zoster at some time during follow-up. Using HIV-infected women with CD4 >750 cells/μL as the reference category, the odds ratios for reporting zoster since the prior visit were: 1.43 (95{\%} CI 0.86-2.37) for CD4 500-749 cells/μL, 2.07 (95{\%} CI 1.27-3.38) for CD4 350-499 cells/μL, 2.72 (95{\%} CI 1.66-4.46) for CD4 200-349 cells/μL, and 3.16 (95{\%} CI 1.92-5.18) for CD4 <200 cells/μL, compared with 0.11 (95{\%} CI 0.046-0.26) for HIV-uninfected women. In multivariate analyses using visits from all HIV-infected women and only those who initiated HAART, lower CD4 cell count was more strongly associated with zoster incidence than were other clinical indicators. Conclusions: Herpes zoster is associated with degree of immunosuppression in HIV-infected women, but even women with high CD4 counts are at greater risk of zoster than HIV-uninfected women.",
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T1 - Herpes zoster in women with and at risk for HIV

T2 - Data from the women's interagency HIV study

AU - Glesby, Marshall J.

AU - Hoover, Donald R.

AU - Tan, Tianren

AU - Shi, Qiuhu

AU - Gao, Wei

AU - French, Audrey L.

AU - Maurer, Toby

AU - Young, Mary

AU - DeHovitz, Jack

AU - Ru, Jenny

AU - Anastos, Kathryn

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N2 - Background: Herpes zoster occurs at all CD4 cell counts in HIV-infected adults. It was hypothesized that even in the era of highly active antiretroviral therapy (HAART), zoster risk is higher in HIV-infected than uninfected women. Methods: Generalized estimating equations modeled self-reported occurrence of zoster between semiannual visits among 1832 HIV-infected and 489 HIV-uninfected women in the Women's Interagency HIV Study followed for up to 7.5 years. Results: A total of 337 (18.4%) HIV-infected and 7 (1.4%) HIV-uninfected women reported zoster at some time during follow-up. Using HIV-infected women with CD4 >750 cells/μL as the reference category, the odds ratios for reporting zoster since the prior visit were: 1.43 (95% CI 0.86-2.37) for CD4 500-749 cells/μL, 2.07 (95% CI 1.27-3.38) for CD4 350-499 cells/μL, 2.72 (95% CI 1.66-4.46) for CD4 200-349 cells/μL, and 3.16 (95% CI 1.92-5.18) for CD4 <200 cells/μL, compared with 0.11 (95% CI 0.046-0.26) for HIV-uninfected women. In multivariate analyses using visits from all HIV-infected women and only those who initiated HAART, lower CD4 cell count was more strongly associated with zoster incidence than were other clinical indicators. Conclusions: Herpes zoster is associated with degree of immunosuppression in HIV-infected women, but even women with high CD4 counts are at greater risk of zoster than HIV-uninfected women.

AB - Background: Herpes zoster occurs at all CD4 cell counts in HIV-infected adults. It was hypothesized that even in the era of highly active antiretroviral therapy (HAART), zoster risk is higher in HIV-infected than uninfected women. Methods: Generalized estimating equations modeled self-reported occurrence of zoster between semiannual visits among 1832 HIV-infected and 489 HIV-uninfected women in the Women's Interagency HIV Study followed for up to 7.5 years. Results: A total of 337 (18.4%) HIV-infected and 7 (1.4%) HIV-uninfected women reported zoster at some time during follow-up. Using HIV-infected women with CD4 >750 cells/μL as the reference category, the odds ratios for reporting zoster since the prior visit were: 1.43 (95% CI 0.86-2.37) for CD4 500-749 cells/μL, 2.07 (95% CI 1.27-3.38) for CD4 350-499 cells/μL, 2.72 (95% CI 1.66-4.46) for CD4 200-349 cells/μL, and 3.16 (95% CI 1.92-5.18) for CD4 <200 cells/μL, compared with 0.11 (95% CI 0.046-0.26) for HIV-uninfected women. In multivariate analyses using visits from all HIV-infected women and only those who initiated HAART, lower CD4 cell count was more strongly associated with zoster incidence than were other clinical indicators. Conclusions: Herpes zoster is associated with degree of immunosuppression in HIV-infected women, but even women with high CD4 counts are at greater risk of zoster than HIV-uninfected women.

KW - Epidemiology

KW - Herpes zoster

KW - HIV infection

KW - Women

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