HER-2/neu: a differentiation marker in adenocarcinoma of the esophagus

Edward R. Sauter; Steven M. Keller; Susan Erner; Melvyn Goldberg

doi:10.1016/0304-3835(93)90205-N

HER-2/neu: a differentiation marker in adenocarcinoma of the esophagus

Edward R. Sauter, Steven M. Keller, Susan Erner, Melvyn Goldberg

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Adenocarcinoma of the esophagus is an aggressive malignancy which is increasing in frequency. The HER-2/neu oncogene product is a putative differentiation marker which exhibits decreased expression in colon carcinoma, while there is overexpression in breast and ovarian cancers. We analyzed the relationship of cell differentiation to HER-2/neu expression in esophageal adenocarcinoma using immunohistochemistry on formalin-fixed, paraffin-embedded material from 14 patients whose tissue contained normal, dysplastic, and malignant features. HER-2/neu expression was detected in 1 of 14 biopsy specimens and 2 of 9 resection specimens. The oncoprotein staining was greatest in normal tissue, less in dysplastic tissue, and not detected in malignant tissue. Our findings, similar to what is seen in the colon, suggest that the HER-2/neu oncogene product is a differentiation marker which is lost in esophageal adenocarcinoma.

Original language	English (US)
Pages (from-to)	41-44
Number of pages	4
Journal	Cancer Letters
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(93)90205-N
State	Published - Nov 30 1993
Externally published	Yes

Keywords

Differentiation marker
Esophageal adenocarcinoma
HER-2/neu

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(93)90205-N

Cite this

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title = "HER-2/neu: a differentiation marker in adenocarcinoma of the esophagus",

abstract = "Adenocarcinoma of the esophagus is an aggressive malignancy which is increasing in frequency. The HER-2/neu oncogene product is a putative differentiation marker which exhibits decreased expression in colon carcinoma, while there is overexpression in breast and ovarian cancers. We analyzed the relationship of cell differentiation to HER-2/neu expression in esophageal adenocarcinoma using immunohistochemistry on formalin-fixed, paraffin-embedded material from 14 patients whose tissue contained normal, dysplastic, and malignant features. HER-2/neu expression was detected in 1 of 14 biopsy specimens and 2 of 9 resection specimens. The oncoprotein staining was greatest in normal tissue, less in dysplastic tissue, and not detected in malignant tissue. Our findings, similar to what is seen in the colon, suggest that the HER-2/neu oncogene product is a differentiation marker which is lost in esophageal adenocarcinoma.",

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T2 - a differentiation marker in adenocarcinoma of the esophagus

AU - Sauter, Edward R.

AU - Keller, Steven M.

AU - Erner, Susan

AU - Goldberg, Melvyn

PY - 1993/11/30

Y1 - 1993/11/30

N2 - Adenocarcinoma of the esophagus is an aggressive malignancy which is increasing in frequency. The HER-2/neu oncogene product is a putative differentiation marker which exhibits decreased expression in colon carcinoma, while there is overexpression in breast and ovarian cancers. We analyzed the relationship of cell differentiation to HER-2/neu expression in esophageal adenocarcinoma using immunohistochemistry on formalin-fixed, paraffin-embedded material from 14 patients whose tissue contained normal, dysplastic, and malignant features. HER-2/neu expression was detected in 1 of 14 biopsy specimens and 2 of 9 resection specimens. The oncoprotein staining was greatest in normal tissue, less in dysplastic tissue, and not detected in malignant tissue. Our findings, similar to what is seen in the colon, suggest that the HER-2/neu oncogene product is a differentiation marker which is lost in esophageal adenocarcinoma.

AB - Adenocarcinoma of the esophagus is an aggressive malignancy which is increasing in frequency. The HER-2/neu oncogene product is a putative differentiation marker which exhibits decreased expression in colon carcinoma, while there is overexpression in breast and ovarian cancers. We analyzed the relationship of cell differentiation to HER-2/neu expression in esophageal adenocarcinoma using immunohistochemistry on formalin-fixed, paraffin-embedded material from 14 patients whose tissue contained normal, dysplastic, and malignant features. HER-2/neu expression was detected in 1 of 14 biopsy specimens and 2 of 9 resection specimens. The oncoprotein staining was greatest in normal tissue, less in dysplastic tissue, and not detected in malignant tissue. Our findings, similar to what is seen in the colon, suggest that the HER-2/neu oncogene product is a differentiation marker which is lost in esophageal adenocarcinoma.

KW - Differentiation marker

KW - Esophageal adenocarcinoma

KW - HER-2/neu

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HER-2/neu: a differentiation marker in adenocarcinoma of the esophagus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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