Hepatocyte transplantation

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Repopulation of the liver with transplanted cells holds significant promise for developing novel therapies. The liver is a most suitable target for treating a variety of genetic, metabolic and acquired diseases. Liver disease, such as chronic viral hepatitis, constitutes an enormous burden worldwide. Advancing liver cell therapy requires insights into mechanisms of cell engraftment and proliferation, as well as unique requirements of specific diseases for correction by cell transplantation. This review highlights recent developments in the area of hepatocyte transplantation. Aspects concerning modulation of cell engraftment, regulation of gene expression and proliferation of transplanted cells are discussed. Other issues concern the current status of clinical applications of hepatocyte transplantation, as well as novel sources of cells that could benefit cell therapy in the future. The general conclusion is that cell therapy has become more practical in recent years and insights into how the normal liver and the diseased liver can be repopulated will offer effective ways to treat many disorders in the near future.

Original languageEnglish (US)
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume17
Issue numberSUPPL. 3
DOIs
StatePublished - 2002

Fingerprint

Hepatocytes
Cell- and Tissue-Based Therapy
Transplantation
Liver
Liver Diseases
Cell Proliferation
Metabolic Diseases
Cell Transplantation
Gene Expression Regulation
Chronic Hepatitis
Therapeutics

Keywords

  • Hepatocyte
  • Liver
  • Transplantation
  • Treatment

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Hepatocyte transplantation. / Gupta, Sanjeev.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 17, No. SUPPL. 3, 2002.

Research output: Contribution to journalArticle

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