Hepatocyte growth factor and clinical diabetes in postmenopausal women

Swapnil N. Rajpathak, Sylvia Wassertheil-Smoller, Jill P. Crandall, Simin Liu, Gloria Y F Ho

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

OBJECTIVE - To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS - A cross-sectional analysis among 892 postmenopausal women within the Women's Health Initiative Observational Study (WHI-OS). RESULTS - HGF levels positively correlated with BMI and homeostasis model assessment for insulin resistance. In the multivariable analysis comparing the highest tertile with the lowest tertile of HGF, the odds ratio for prevalent diabetes was 2.47 (95% CI [1.12-5.47], P for trend= 0.014) after accounting for age, race, BMI, and other risk factors for diabetes. CONCLUSIONS - HGF levels are associated with the presence of type 2 diabetes in postmenopausal women. Future studies should consider the prospective evaluation of the association of HGF with the development of type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)2013-2015
Number of pages3
JournalDiabetes Care
Volume33
Issue number9
DOIs
StatePublished - Sep 2010

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Hepatocyte Growth Factor
Type 2 Diabetes Mellitus
Women's Health
Observational Studies
Insulin Resistance
Homeostasis
Research Design
Obesity
Cross-Sectional Studies
Odds Ratio

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Rajpathak, S. N., Wassertheil-Smoller, S., Crandall, J. P., Liu, S., & Ho, G. Y. F. (2010). Hepatocyte growth factor and clinical diabetes in postmenopausal women. Diabetes Care, 33(9), 2013-2015. https://doi.org/10.2337/dc10-0710

Hepatocyte growth factor and clinical diabetes in postmenopausal women. / Rajpathak, Swapnil N.; Wassertheil-Smoller, Sylvia; Crandall, Jill P.; Liu, Simin; Ho, Gloria Y F.

In: Diabetes Care, Vol. 33, No. 9, 09.2010, p. 2013-2015.

Research output: Contribution to journalArticle

Rajpathak, SN, Wassertheil-Smoller, S, Crandall, JP, Liu, S & Ho, GYF 2010, 'Hepatocyte growth factor and clinical diabetes in postmenopausal women', Diabetes Care, vol. 33, no. 9, pp. 2013-2015. https://doi.org/10.2337/dc10-0710
Rajpathak, Swapnil N. ; Wassertheil-Smoller, Sylvia ; Crandall, Jill P. ; Liu, Simin ; Ho, Gloria Y F. / Hepatocyte growth factor and clinical diabetes in postmenopausal women. In: Diabetes Care. 2010 ; Vol. 33, No. 9. pp. 2013-2015.
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