Hepatocellular sinusoidal membrane organic anion transport and transporters

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This review focuses on oatp, a rat liver protein that has been cloned on the basis of its ability to transport organic anions such as bilirubin and sulfobromophthalein (BSP). Although other proteins have been suggested as having bilirubin or BSP transport activity, these data have primarily been indirect, and their cloning and expression have not yet been accomplished. Although preliminary data suggest that organic anion transporting polypeptide (oatp) accounts for a significant amount of BSP transport into the hepatocyte, there is certainly the possibility that other transporters exist. In addition, oatp appears to be a member of a new family of integral membrane transport proteins that may have overlapping substrate specificities. Organic anions such as bilirubin and sulfobromophthalein (BSP) circulate bound tightly to albumin from which they are rapidly extracted by hepatocytes. This process of organic anion uptake has been the subject of extensive investigation over many years. Although details remain unresolved, much has been learned recently regarding the mechanisms of organic anion transport. This article will examine the history and current status of this field.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalSeminars in Liver Disease
Volume16
Issue number2
StatePublished - 1996

Fingerprint

Organic Anion Transporters
Anions
Sulfobromophthalein
Bilirubin
Membranes
Peptides
Hepatocytes
Membrane Transport Proteins
Substrate Specificity
Organism Cloning
Albumins
Membrane Proteins
Proteins
History
Liver

Keywords

  • anion transport
  • BSP
  • oatp

ASJC Scopus subject areas

  • Hepatology

Cite this

Hepatocellular sinusoidal membrane organic anion transport and transporters. / Wolkoff, Allan W.

In: Seminars in Liver Disease, Vol. 16, No. 2, 1996, p. 121-127.

Research output: Contribution to journalArticle

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