Hepatoblastoma in a mosaic trisomy 18 patient

Elaine Maria Pereira, Robert W. Marion, K.h. Ramesh, Jane S. Kim, Michelle R. Ewart, Rosanna Ricafort

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We report a case of hepatoblastoma in a 10-year-old girl with mosaic-type trisomy 18. A comprehensive literature review reveals only 2 cases involving mosaic trisomy 18 patients. Our patient underwent an abbreviated chemotherapy course before complete surgical resection. Her hepatoblastoma did not contain cells with trisomy 18. The conservative management approach resulted in a successful outcome; she remains disease free >2 years after surgery. Along with presenting a literature review, this report demonstrates a favorable outcome in a mosaic trisomy 18 child with hepatoblastoma where tumor cells lacked a trisomy 18 karyotype.

Original languageEnglish (US)
JournalJournal of Pediatric Hematology/Oncology
Volume34
Issue number4
DOIs
StatePublished - May 2012

Fingerprint

Hepatoblastoma
Karyotype
Trisomy 18
Drug Therapy
Neoplasms

Keywords

  • Cytogenetics
  • hepatoblastoma
  • Mosaic
  • Trisomy 18

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Hepatoblastoma in a mosaic trisomy 18 patient. / Pereira, Elaine Maria; Marion, Robert W.; Ramesh, K.h.; Kim, Jane S.; Ewart, Michelle R.; Ricafort, Rosanna.

In: Journal of Pediatric Hematology/Oncology, Vol. 34, No. 4, 05.2012.

Research output: Contribution to journalArticle

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