Heparan sulfate-like immunoreactivity in the spinal cord in motor neuron disease

Takeo Kato, Tadashi Katagiri, Yukihiro Shikama, Keiji Kurita, Itaru Toyoshima, Asao Hirano, Manabu Wada, Hideo Sasaki

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13 Scopus citations

Abstract

The spinal cords from eight autopsy cases of sporadic motor neuron disease (MND) and two control cases were immunohistochemically examined using anti-bodies directed to neurofilament proteins (anti-Nf) and to heparan sulfate (HepSS-1). Variable numbers of spheroids were observed in the anterior horns in the MND cases. In one case of MND, one third to half of the remaining anterior horn cells contained conglomerate inclusions in their perikarya. These pathological structures were not encountered in the control cases. The immunohistochemical study revealed that both anti-Nf and HepSS-1 intensely labelled all spheroids and conglomerate inclusions in the MND cases. The colocalization of heparan sulfate with neurofilamentous accumulation suggests that heparan sulfate is required for the aggregation of neurofilaments, resulting in the formation of spheroids and conglomerate inclusions in MND.

Original languageEnglish (US)
Pages (from-to)663-665
Number of pages3
JournalActa neuropathologica
Volume85
Issue number6
DOIs
Publication statusPublished - May 1 1993

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Keywords

  • Conglomerate inclusion
  • Heparan sulfate proteoglycan
  • Motor neuron disease
  • Neurofilament
  • Spheroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Kato, T., Katagiri, T., Shikama, Y., Kurita, K., Toyoshima, I., Hirano, A., ... Sasaki, H. (1993). Heparan sulfate-like immunoreactivity in the spinal cord in motor neuron disease. Acta neuropathologica, 85(6), 663-665. https://doi.org/10.1007/BF00334678