Hemodynamic effects of morphine in cardiac disease

L. Gould, C. V R Reddy, K. C. Oh, Soo G. Kim, W. H. Becker

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The hemodynamic effects of intravenous morphine were documented by right heart catheterization in six patients with an acute uncomplicated transmural myocardial infarction one to three days after the onset of symptoms. Intracardiac pressures, brachial artery pressure, and cardiac output were determined before and 15 minutes after the termination of the morphine infusion. 5 milligrams morphine was given intravenously over a 10 minute period. The brachial artery pressure fell from a mean of 78 to a mean of 73 mm Hg (NS). As a result of morphine administration, the average cardiac index decreased from 2.68 to 2.31 liters/min-m2 (P<0.05) and the stroke index decreased from 27 to 22 ml/beat-m2 (P<0.05). Only small changes were observed in the intracardiac pressures.

Original languageEnglish (US)
Pages (from-to)448-456
Number of pages9
JournalJournal of Clinical Pharmacology
Volume18
Issue number10
StatePublished - 1978
Externally publishedYes

Fingerprint

Morphine
Heart Diseases
Hemodynamics
Pressure
Brachial Artery
Cardiac Catheterization
Cardiac Output
Stroke
Myocardial Infarction

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Gould, L., Reddy, C. V. R., Oh, K. C., Kim, S. G., & Becker, W. H. (1978). Hemodynamic effects of morphine in cardiac disease. Journal of Clinical Pharmacology, 18(10), 448-456.

Hemodynamic effects of morphine in cardiac disease. / Gould, L.; Reddy, C. V R; Oh, K. C.; Kim, Soo G.; Becker, W. H.

In: Journal of Clinical Pharmacology, Vol. 18, No. 10, 1978, p. 448-456.

Research output: Contribution to journalArticle

Gould, L, Reddy, CVR, Oh, KC, Kim, SG & Becker, WH 1978, 'Hemodynamic effects of morphine in cardiac disease', Journal of Clinical Pharmacology, vol. 18, no. 10, pp. 448-456.
Gould L, Reddy CVR, Oh KC, Kim SG, Becker WH. Hemodynamic effects of morphine in cardiac disease. Journal of Clinical Pharmacology. 1978;18(10):448-456.
Gould, L. ; Reddy, C. V R ; Oh, K. C. ; Kim, Soo G. ; Becker, W. H. / Hemodynamic effects of morphine in cardiac disease. In: Journal of Clinical Pharmacology. 1978 ; Vol. 18, No. 10. pp. 448-456.
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