Hemodynamic consequences of afterload reduction in patients with valvular abnormalities

L. Gould, C. V.R. Reddy, W. Becker, S. G. Kim, K. C. Oh

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Ten patients with mitral insufficiency, eight patients with aortic insufficiency and eight patients with mitral stenosis were studied by right- and left-heart catheterization. Hemodynamic observations were made during a control period and during the infusion of phentolamine at a rate of 0.3 mg/min. The patients with mitral insufficiency and aortic insufficiency responded to phentolamine with a significant decline in the right and left ventricular filling pressures, pulmonary-artery mean pressure, peripheral resistance and arteriovenous oxygen difference. A significant increase in the cardiac index was seen in both groups. The patients with mitral stenosis did not show any hemodynamic improvement with the phentolamine infusion.

Original languageEnglish (US)
Pages (from-to)445-458
Number of pages14
JournalJournal of Chronic Diseases
Volume33
Issue number7
DOIs
Publication statusPublished - 1980
Externally publishedYes

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ASJC Scopus subject areas

  • Epidemiology

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