Hematopoietic stem cell trafficking: Regulated adhesion and attraction to bone marrow microenvironment

Simón Méndez-Ferrer, Paul S. Frenette

Research output: Chapter in Book/Report/Conference proceedingConference contribution

60 Scopus citations

Abstract

Hematopoiesis takes place preferentially within bone cavities, suggesting that bone-derived factors contribute to blood formation. Hematopoietic stem and progenitor cells (HSPCs) can be mobilized from the bone marrow parenchyma to the circulation by various agonists whose common downstream action leads to alteration in the expression or function of the chemokine CXCL12 and adhesion molecules mediating migration. Granulocyte colony-stimulating factor (G-CSF), the most prevalent drug used to mobilize HSPCs, dramatically suppresses osteoblast function. Recent studies suggest that G-CSF-mediated suppression requires signals from the sympathetic nervous system (SNS). This review summarizes emerging concepts thought to contribute to stem cell migration.

Original languageEnglish (US)
Title of host publicationSkeletal Biology and Medicine, Part A
Subtitle of host publicationAspects of Bone Morphogenesis and Remodeling
PublisherBlackwell Publishing Inc.
Pages392-413
Number of pages22
ISBN (Print)9781573316842
DOIs
StatePublished - Nov 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1116
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Adhesion
  • Hematopoietic stem and progenitor cells
  • Homing
  • Mobilization
  • Stem cell niche
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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