Hematopoietic stem cell trafficking: Regulated adhesion and attraction to bone marrow microenvironment

Simón Méndez-Ferrer; Paul S. Frenette

doi:10.1196/annals.1402.086

Hematopoietic stem cell trafficking: Regulated adhesion and attraction to bone marrow microenvironment

Simón Méndez-Ferrer, Paul S. Frenette

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

69 Scopus citations

Abstract

Hematopoiesis takes place preferentially within bone cavities, suggesting that bone-derived factors contribute to blood formation. Hematopoietic stem and progenitor cells (HSPCs) can be mobilized from the bone marrow parenchyma to the circulation by various agonists whose common downstream action leads to alteration in the expression or function of the chemokine CXCL12 and adhesion molecules mediating migration. Granulocyte colony-stimulating factor (G-CSF), the most prevalent drug used to mobilize HSPCs, dramatically suppresses osteoblast function. Recent studies suggest that G-CSF-mediated suppression requires signals from the sympathetic nervous system (SNS). This review summarizes emerging concepts thought to contribute to stem cell migration.

Original language	English (US)
Title of host publication	Skeletal Biology and Medicine, Part A
Subtitle of host publication	Aspects of Bone Morphogenesis and Remodeling
Publisher	Blackwell Publishing Inc.
Pages	392-413
Number of pages	22
ISBN (Print)	9781573316842
DOIs	https://doi.org/10.1196/annals.1402.086
State	Published - Nov 2007
Externally published	Yes

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1116
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Adhesion
Hematopoietic stem and progenitor cells
Homing
Mobilization
Stem cell niche
Sympathetic nervous system

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

Access to Document

10.1196/annals.1402.086

Cite this

Méndez-Ferrer, S., & Frenette, P. S. (2007). Hematopoietic stem cell trafficking: Regulated adhesion and attraction to bone marrow microenvironment. In Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling (pp. 392-413). (Annals of the New York Academy of Sciences; Vol. 1116). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1402.086

Hematopoietic stem cell trafficking: Regulated adhesion and attraction to bone marrow microenvironment. / Méndez-Ferrer, Simón; Frenette, Paul S.
Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling. Blackwell Publishing Inc., 2007. p. 392-413 (Annals of the New York Academy of Sciences; Vol. 1116).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Hematopoietic stem cell trafficking: Regulated adhesion and attraction to bone marrow microenvironment

Abstract

Publication series

Keywords

ASJC Scopus subject areas

Access to Document

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