Hematopoietic stem cell niche maintenance during homeostasis and regeneration

Avital Mendelson, Paul S. Frenette

Research output: Contribution to journalArticle

318 Citations (Scopus)

Abstract

The bone marrow niche has mystified scientists for many years, leading to widespread investigation to shed light into its molecular and cellular composition. Considerable efforts have been devoted toward uncovering the regulatory mechanisms of hematopoietic stem cell (HSC) niche maintenance. Recent advances in imaging and genetic manipulation of mouse models have allowed the identification of distinct vascular niches that have been shown to orchestrate the balance between quiescence, proliferation and regeneration of the bone marrow after injury. Here we highlight the recently discovered intrinsic mechanisms, microenvironmental interactions and communication with surrounding cells involved in HSC regulation, during homeostasis and in regeneration after injury and discuss their implications for regenerative therapy.

Original languageEnglish (US)
Pages (from-to)833-846
Number of pages14
JournalNature Medicine
Volume20
Issue number8
DOIs
StatePublished - 2014

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Stem Cell Niche
Hematopoietic Stem Cells
Stem cells
Regeneration
Bone
Homeostasis
Bone Marrow
Maintenance
Wounds and Injuries
Blood Vessels
Identification (control systems)
Communication
Imaging techniques
Chemical analysis
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hematopoietic stem cell niche maintenance during homeostasis and regeneration. / Mendelson, Avital; Frenette, Paul S.

In: Nature Medicine, Vol. 20, No. 8, 2014, p. 833-846.

Research output: Contribution to journalArticle

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