TY - JOUR
T1 - Hematopoietic Stem Cell Metabolism during Development and Aging
AU - Nakamura-Ishizu, Ayako
AU - Ito, Keisuke
AU - Suda, Toshio
N1 - Funding Information:
This study was supported by the National Medical Research Council Grant of Singapore Translational Research Investigator Award (NMRC/STaR/18 may-0004/2019-2023, to T.S.), grants from the National Institutes of Health (to K.I.), Research Scholar of the Leukemia and Lymphoma Society (to K.I.), KAKEN Grant-in-Aid for Scientific Research (S) ( 18H05284 to T.S.), KAKEN Grant-in-Aid for Scientific Research (C) ( 18K08364 to A.N.-I.), and a grant from Japan Leukemia Research Fund (to A.N.-I.).
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/7/20
Y1 - 2020/7/20
N2 - Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.
AB - Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.
UR - http://www.scopus.com/inward/record.url?scp=85087994658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087994658&partnerID=8YFLogxK
U2 - 10.1016/j.devcel.2020.06.029
DO - 10.1016/j.devcel.2020.06.029
M3 - Review article
C2 - 32693057
AN - SCOPUS:85087994658
SN - 1534-5807
VL - 54
SP - 239
EP - 255
JO - Developmental Cell
JF - Developmental Cell
IS - 2
ER -