Hematopoietic stem cell fate through metabolic control

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Hematopoietic stem cells maintain a quiescent state in the bone marrow to preserve their self-renewal capacity, but also undergo cell divisions as required. Organelles such as the mitochondria sustain cumulative damage during these cell divisions and this damage may eventually compromise the cells' self-renewal capacity. Hematopoietic stem cell divisions result in either self-renewal or differentiation, with the balance between the two affecting hematopoietic homeostasis directly; however, the heterogeneity of available hematopoietic stem cell-enriched fractions, together with the technical challenges of observing hematopoietic stem cell behavior, has long hindered the analysis of individual hematopoietic stem cells and prevented the elucidation of this process. Recent advances in genetic models, metabolomics analyses, and single-cell approaches have revealed the contributions made to hematopoietic stem cell self-renewal by metabolic cues, mitochondrial biogenesis, and autophagy/mitophagy, which have highlighted mitochondrial quality control as a key factor in the equilibrium of hematopoietic stem cells. A deeper understanding of precisely how specific modes of metabolism control hematopoietic stem cells fate at the single-cell level is therefore not only of great biological interest, but will also have clear clinical implications for the development of therapies for hematological diseases.

Original languageEnglish (US)
JournalExperimental Hematology
DOIs
StateAccepted/In press - Jan 1 2018

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Hematopoietic Stem Cells
Cell Division
Mitochondrial Degradation
Single-Cell Analysis
Metabolomics
Hematologic Diseases
Genetic Models
Autophagy
Organelle Biogenesis
Quality Control
Organelles
Cues
Mitochondria
Homeostasis
Bone Marrow

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

Cite this

Hematopoietic stem cell fate through metabolic control. / Ito, Kyoko; Ito, Keisuke.

In: Experimental Hematology, 01.01.2018.

Research output: Contribution to journalArticle

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