Heat shock proteins in histoplasma and paracoccidioides

Levi G. Cleare, Daniel Zamith-Miranda, Joshua D. Nosanchuk

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Heat shock proteins (Hsps) are highly conserved biomolecules that are constitutively expressed and generally upregulated in response to various stress conditions (biotic and abiotic). Hsps have diverse functions, categorizations, and classifications. Their adaptive expression in fungi indicates their significance in these diverse species, particularly in dimorphic pathogens. Histoplasma capsulatum and Paracoccidioides species are dimorphic fungi that are the causative agents of histoplasmosis and paracoccidioidomycosis, respectively. This minireview focuses on the pathobiology of Hsps, with particular emphasis on their roles in the morphogenesis and virulence of Histoplasma and Paracoccidioides and the potential roles of active and passive immunization against Hsps in protection against infection with these fungi.

Original languageEnglish (US)
Article numbere00221-17
JournalClinical and Vaccine Immunology
Volume24
Issue number11
DOIs
StatePublished - Nov 2017

Keywords

  • Dimorphic fungal pathogen
  • Fungi
  • Heat shock proteins
  • Histoplasmosis
  • Immunotherapeutics
  • Immunotherapy
  • Paracoccidioidomycosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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