TY - JOUR
T1 - Heat-shock proteins in cardiovascular disease
AU - Madrigal-Matute, Julio
AU - Martin-Ventura, Jose Luis
AU - Blanco-Colio, Luis Miguel
AU - Egido, Jesus
AU - Michel, Jean Baptiste
AU - Meilhac, Olivier
N1 - Funding Information:
The authors’ work have been supported by the Leducq Foundation, the Spanish Ministerio de Ciencia y Tecnología (SAF 2010-21852), CAM (S2006/GEN-0247), Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Redes RECAVA (RD06/0014/0035; RD06/0014/0008), and European Network (HEALTH F2-2008-200647) and EUS2008-03565. The authors would like to thank Dr. Mary Osborne-Pellegrin for editing this chapter.
PY - 2011
Y1 - 2011
N2 - Heat-shock proteins (HSPs) belong to a group of highly conserved families of proteins expressed by all cells and organisms and their expression may be constitutive or inducible. They are generally considered as protective molecules against different types of stress and have numerous intracellular functions. Secretion or release of HSPs has also been described, and potential roles for extracellular HSPs reported. HSP expression is modulated by different stimuli involved in all steps of atherogenesis including oxidative stress, proteolytic aggression, or inflammation. Also, antibodies to HSPs may be used to monitor the response to different types of stress able to induce changes in HSP levels. In the present review, we will focus on the potential implication of HSPs in atherogenesis and discuss the limitations to the use of HSPs and anti-HSPs as biomarkers of atherothrombosis. HSPs could also be considered as potential therapeutic targets to reinforce vascular defenses and delay or avoid clinical complications associated with atherothrombosis.
AB - Heat-shock proteins (HSPs) belong to a group of highly conserved families of proteins expressed by all cells and organisms and their expression may be constitutive or inducible. They are generally considered as protective molecules against different types of stress and have numerous intracellular functions. Secretion or release of HSPs has also been described, and potential roles for extracellular HSPs reported. HSP expression is modulated by different stimuli involved in all steps of atherogenesis including oxidative stress, proteolytic aggression, or inflammation. Also, antibodies to HSPs may be used to monitor the response to different types of stress able to induce changes in HSP levels. In the present review, we will focus on the potential implication of HSPs in atherogenesis and discuss the limitations to the use of HSPs and anti-HSPs as biomarkers of atherothrombosis. HSPs could also be considered as potential therapeutic targets to reinforce vascular defenses and delay or avoid clinical complications associated with atherothrombosis.
KW - Atherosclerosis
KW - Atherothrombosis
KW - Gene therapy
KW - Heat-shock protein
KW - Lipoprotein
KW - Plaque stability
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U2 - 10.1016/B978-0-12-387025-4.00001-7
DO - 10.1016/B978-0-12-387025-4.00001-7
M3 - Article
C2 - 21874755
AN - SCOPUS:79953876832
SN - 0065-2423
VL - 54
SP - 1
EP - 43
JO - Advances in Clinical Chemistry
JF - Advances in Clinical Chemistry
ER -
