Heat-shock proteins in cardiovascular disease

Julio Madrigal-Matute, Jose Luis Martin-Ventura, Luis Miguel Blanco-Colio, Jesus Egido, Jean Baptiste Michel, Olivier Meilhac

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Heat-shock proteins (HSPs) belong to a group of highly conserved families of proteins expressed by all cells and organisms and their expression may be constitutive or inducible. They are generally considered as protective molecules against different types of stress and have numerous intracellular functions. Secretion or release of HSPs has also been described, and potential roles for extracellular HSPs reported. HSP expression is modulated by different stimuli involved in all steps of atherogenesis including oxidative stress, proteolytic aggression, or inflammation. Also, antibodies to HSPs may be used to monitor the response to different types of stress able to induce changes in HSP levels. In the present review, we will focus on the potential implication of HSPs in atherogenesis and discuss the limitations to the use of HSPs and anti-HSPs as biomarkers of atherothrombosis. HSPs could also be considered as potential therapeutic targets to reinforce vascular defenses and delay or avoid clinical complications associated with atherothrombosis.

Original languageEnglish (US)
Pages (from-to)1-43
Number of pages43
JournalAdvances in Clinical Chemistry
Volume54
DOIs
StatePublished - 2011

Keywords

  • Atherosclerosis
  • Atherothrombosis
  • Gene therapy
  • Heat-shock protein
  • Lipoprotein
  • Plaque stability

ASJC Scopus subject areas

  • Chemistry(all)
  • Clinical Biochemistry

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