Las proteínas de choque térmico (heat shock proteins) como potenciales dianas terapéuticas en aterosclerosis

Translated title of the contribution: Heat shock proteins as potential therapeutic targets in atherosclerosis

Julio Madrigal-Matute, Óscar López-Franco, Luis M. Blanco-Colio, Begoña Muñoz-García, Priscila Ramos-Mozo, Melany Van Oostrom, Olivier Meilhac, Jean Baptiste Michel, Jesús Egido, José L. Martín Ventura

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Heat shock proteins (HSP) are a family ofproteins present in the majority of cells and are produced s a cell protection mechanism against adverse conditions. HSP are present in both atherosclerotic plaques and healthy arteries, although their role in atherosclerosis remain to be defined. Our objective was to investigate the effect of HSP90 inhibitors in the modulation of the different processes involved in atherogenesis. We have used an HSP90 inhibitor (17-AAG), which is able to increase the heat shock response. Treatment of monocytes and vascular smooth muscle cells with 17-AAG increased HSP70 expression. Under these conditions, 17-AAG was able to decrease NADPH oxidase activity induced by TNF-α. Stimulation of cells with cytokines induced the activation of different signalling pathways (e.g. MAPKs and NF-κB) and increased the levels of cytokines such as IL-6, which was diminished by HSP90 inhibitors. Finally, while treatment with 17-AAG prevented the apoptosis of cells induced proapoptotic stimuli, HSP27 silencing increased apoptosis induced by elastase. HSP90 inhibitors decrease pro-atherogenic processes, suggesting that these drugs may have beneficial effects in the treatment of atherosclerosis.

Translated title of the contributionHeat shock proteins as potential therapeutic targets in atherosclerosis
Original languageSpanish
Pages (from-to)163-172
Number of pages10
JournalClinica e Investigacion en Arteriosclerosis
Volume21
Issue number4
DOIs
StatePublished - Aug 2009

Keywords

  • Apoptosis
  • Atherosclerosis
  • Heat shock proteins
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Heat shock proteins as potential therapeutic targets in atherosclerosis'. Together they form a unique fingerprint.

Cite this