Heart transplantation to a physiologic single lung in patients with congenital heart disease

Jacqueline M. Lamour, Daphne T. Hsu, Jan M. Quaegebeur, Sean P. Pinney, Seema R. Mital, Ralph S. Mosca, Jonathan M. Chen, Linda J. Addonizio

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Heart-lung transplantation has been recommended for patients with end-stage congenital heart disease (CHD) and single-lung physiology due to either discontinuous pulmonary arteries (PAs) and unilateral PA hypertension (HTN) or absence of 1 PA. Eleven patients with CHD and single-lung physiology underwent heart transplantation (HT). Diagnoses included: tetralogy of Fallot, absent left PA (n = 4); single-ventricle s/p classic Glenn (n = 7), with absent left PA (n = 1); and severe left PA HTN (n = 6). Mean time from last surgery was 13 ± 8 years; mean number of operations (op) was 3.2 ± 1.7. Mean age was 21 ± 11 years (range 9.5 to 43). Complications and procedures before HT included hemoptysis (n = 2), plastic bronchitis (n = 1) and interventional catheterization (n = 6). Mean cardiopulmonary bypass and ischemic time was 275 ± 72 and 268 ± 75 minutes, respectively. Mean time to extubation was 4.6 ± 3.2 days, and mean length of stay was 19 ± 7 days. Post-operative morbidity included bleeding (n = 4), vocal cord paralysis (n = 1) and coil embolization of aortopulmonary collaterals (n = 3). Early post-operative survival was 82%. Cause of death was aortic rupture (n = 1) and bleeding (n = 1). Eight patients are alive 4 years (range 0.9 to 7.6) after HT. PA continuity was established in 6 patients; post-HT lung perfusion scan showed no increase in perfusion to the left PA. One patient died from rejection 3 years post-HT. HT can be performed successfully in patients with single-lung physiology. HT is the procedure of choice in patients with end-stage CHD and a physiologic single lung.

Original languageEnglish (US)
Pages (from-to)948-953
Number of pages6
JournalJournal of Heart and Lung Transplantation
Volume23
Issue number8
DOIs
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

Heart Transplantation
Pulmonary Artery
Heart Diseases
Lung
Heart-Lung Transplantation
Pulmonary Hypertension
Perfusion
Hemorrhage
Vocal Cord Paralysis
Aortic Rupture
Tetralogy of Fallot
Hemoptysis
Bronchitis
Cardiopulmonary Bypass
Catheterization
Cause of Death
Length of Stay
Morbidity
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Heart transplantation to a physiologic single lung in patients with congenital heart disease. / Lamour, Jacqueline M.; Hsu, Daphne T.; Quaegebeur, Jan M.; Pinney, Sean P.; Mital, Seema R.; Mosca, Ralph S.; Chen, Jonathan M.; Addonizio, Linda J.

In: Journal of Heart and Lung Transplantation, Vol. 23, No. 8, 08.2004, p. 948-953.

Research output: Contribution to journalArticle

Lamour, Jacqueline M. ; Hsu, Daphne T. ; Quaegebeur, Jan M. ; Pinney, Sean P. ; Mital, Seema R. ; Mosca, Ralph S. ; Chen, Jonathan M. ; Addonizio, Linda J. / Heart transplantation to a physiologic single lung in patients with congenital heart disease. In: Journal of Heart and Lung Transplantation. 2004 ; Vol. 23, No. 8. pp. 948-953.
@article{d9f4a86e3a1a4f28b27e92323a717dee,
title = "Heart transplantation to a physiologic single lung in patients with congenital heart disease",
abstract = "Heart-lung transplantation has been recommended for patients with end-stage congenital heart disease (CHD) and single-lung physiology due to either discontinuous pulmonary arteries (PAs) and unilateral PA hypertension (HTN) or absence of 1 PA. Eleven patients with CHD and single-lung physiology underwent heart transplantation (HT). Diagnoses included: tetralogy of Fallot, absent left PA (n = 4); single-ventricle s/p classic Glenn (n = 7), with absent left PA (n = 1); and severe left PA HTN (n = 6). Mean time from last surgery was 13 ± 8 years; mean number of operations (op) was 3.2 ± 1.7. Mean age was 21 ± 11 years (range 9.5 to 43). Complications and procedures before HT included hemoptysis (n = 2), plastic bronchitis (n = 1) and interventional catheterization (n = 6). Mean cardiopulmonary bypass and ischemic time was 275 ± 72 and 268 ± 75 minutes, respectively. Mean time to extubation was 4.6 ± 3.2 days, and mean length of stay was 19 ± 7 days. Post-operative morbidity included bleeding (n = 4), vocal cord paralysis (n = 1) and coil embolization of aortopulmonary collaterals (n = 3). Early post-operative survival was 82{\%}. Cause of death was aortic rupture (n = 1) and bleeding (n = 1). Eight patients are alive 4 years (range 0.9 to 7.6) after HT. PA continuity was established in 6 patients; post-HT lung perfusion scan showed no increase in perfusion to the left PA. One patient died from rejection 3 years post-HT. HT can be performed successfully in patients with single-lung physiology. HT is the procedure of choice in patients with end-stage CHD and a physiologic single lung.",
author = "Lamour, {Jacqueline M.} and Hsu, {Daphne T.} and Quaegebeur, {Jan M.} and Pinney, {Sean P.} and Mital, {Seema R.} and Mosca, {Ralph S.} and Chen, {Jonathan M.} and Addonizio, {Linda J.}",
year = "2004",
month = "8",
doi = "10.1016/j.healun.2004.06.012",
language = "English (US)",
volume = "23",
pages = "948--953",
journal = "Journal of Heart and Lung Transplantation",
issn = "1053-2498",
publisher = "Elsevier USA",
number = "8",

}

TY - JOUR

T1 - Heart transplantation to a physiologic single lung in patients with congenital heart disease

AU - Lamour, Jacqueline M.

AU - Hsu, Daphne T.

AU - Quaegebeur, Jan M.

AU - Pinney, Sean P.

AU - Mital, Seema R.

AU - Mosca, Ralph S.

AU - Chen, Jonathan M.

AU - Addonizio, Linda J.

PY - 2004/8

Y1 - 2004/8

N2 - Heart-lung transplantation has been recommended for patients with end-stage congenital heart disease (CHD) and single-lung physiology due to either discontinuous pulmonary arteries (PAs) and unilateral PA hypertension (HTN) or absence of 1 PA. Eleven patients with CHD and single-lung physiology underwent heart transplantation (HT). Diagnoses included: tetralogy of Fallot, absent left PA (n = 4); single-ventricle s/p classic Glenn (n = 7), with absent left PA (n = 1); and severe left PA HTN (n = 6). Mean time from last surgery was 13 ± 8 years; mean number of operations (op) was 3.2 ± 1.7. Mean age was 21 ± 11 years (range 9.5 to 43). Complications and procedures before HT included hemoptysis (n = 2), plastic bronchitis (n = 1) and interventional catheterization (n = 6). Mean cardiopulmonary bypass and ischemic time was 275 ± 72 and 268 ± 75 minutes, respectively. Mean time to extubation was 4.6 ± 3.2 days, and mean length of stay was 19 ± 7 days. Post-operative morbidity included bleeding (n = 4), vocal cord paralysis (n = 1) and coil embolization of aortopulmonary collaterals (n = 3). Early post-operative survival was 82%. Cause of death was aortic rupture (n = 1) and bleeding (n = 1). Eight patients are alive 4 years (range 0.9 to 7.6) after HT. PA continuity was established in 6 patients; post-HT lung perfusion scan showed no increase in perfusion to the left PA. One patient died from rejection 3 years post-HT. HT can be performed successfully in patients with single-lung physiology. HT is the procedure of choice in patients with end-stage CHD and a physiologic single lung.

AB - Heart-lung transplantation has been recommended for patients with end-stage congenital heart disease (CHD) and single-lung physiology due to either discontinuous pulmonary arteries (PAs) and unilateral PA hypertension (HTN) or absence of 1 PA. Eleven patients with CHD and single-lung physiology underwent heart transplantation (HT). Diagnoses included: tetralogy of Fallot, absent left PA (n = 4); single-ventricle s/p classic Glenn (n = 7), with absent left PA (n = 1); and severe left PA HTN (n = 6). Mean time from last surgery was 13 ± 8 years; mean number of operations (op) was 3.2 ± 1.7. Mean age was 21 ± 11 years (range 9.5 to 43). Complications and procedures before HT included hemoptysis (n = 2), plastic bronchitis (n = 1) and interventional catheterization (n = 6). Mean cardiopulmonary bypass and ischemic time was 275 ± 72 and 268 ± 75 minutes, respectively. Mean time to extubation was 4.6 ± 3.2 days, and mean length of stay was 19 ± 7 days. Post-operative morbidity included bleeding (n = 4), vocal cord paralysis (n = 1) and coil embolization of aortopulmonary collaterals (n = 3). Early post-operative survival was 82%. Cause of death was aortic rupture (n = 1) and bleeding (n = 1). Eight patients are alive 4 years (range 0.9 to 7.6) after HT. PA continuity was established in 6 patients; post-HT lung perfusion scan showed no increase in perfusion to the left PA. One patient died from rejection 3 years post-HT. HT can be performed successfully in patients with single-lung physiology. HT is the procedure of choice in patients with end-stage CHD and a physiologic single lung.

UR - http://www.scopus.com/inward/record.url?scp=4243201447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4243201447&partnerID=8YFLogxK

U2 - 10.1016/j.healun.2004.06.012

DO - 10.1016/j.healun.2004.06.012

M3 - Article

VL - 23

SP - 948

EP - 953

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

SN - 1053-2498

IS - 8

ER -