Heart Transplantation in Human Immunodeficiency Virus-Positive Patients

Nir Uriel, Ulrich P. Jorde, Vlad Cotarlan, Paolo C. Colombo, Maryjane Farr, Susan W. Restaino, Katherine Lietz, Yoshifuma Naka, Mario C. Deng, Donna Mancini

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Human immunodeficiency virus (HIV) infection is widely considered a contraindication for cardiac transplantation. However, with the newer anti-retroviral drugs, the estimated 10-year survival after seroconversion is exceeds 90%. This case series describes the intermediate range outcome of HIV-positive cardiac transplant recipients. Methods: A retrospective analysis of 1679 cardiac transplant patients was undertaken to identify HIV-positive recipients. Results: Seven patients were identified. Five (4 men) were diagnosed with HIV before transplantation and 2 patients seroconverted after transplantation. Dilated cardiomyopathy was the indication for transplant in all patients. The 5 HIV recipients were aged 42 ± 8 years, and time after HIV seroconversion averaged 9.5 years. All underwent cardiac transplantation as high-risk candidates. The CD4 count was 554 ± 169 cells/μl, and viral load was undetectable in all patients at the time of transplantation. Two patients seroconverted to HIV-positive status at 1 and 7 years after transplant. No AIDS-defining illness was observed in any patient before or after transplant. Six patients received highly active anti-retroviral therapy. Viral load remained low in the presence of immunosuppression. All patients are alive with a follow-up from transplant of 57 ± 78.9 months. Conclusion: Excellent intermediate term outcome is noted in carefully selected HIV-positive patients. No significant AIDS-related infections or complications occurred.

Original languageEnglish (US)
Pages (from-to)667-669
Number of pages3
JournalJournal of Heart and Lung Transplantation
Volume28
Issue number7
DOIs
StatePublished - Jul 2009
Externally publishedYes

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Heart Transplantation
HIV
Transplants
Transplantation
Viral Load
Acquired Immunodeficiency Syndrome
Dilated Cardiomyopathy
Virus Diseases
CD4 Lymphocyte Count
Immunosuppression
Survival

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Heart Transplantation in Human Immunodeficiency Virus-Positive Patients. / Uriel, Nir; Jorde, Ulrich P.; Cotarlan, Vlad; Colombo, Paolo C.; Farr, Maryjane; Restaino, Susan W.; Lietz, Katherine; Naka, Yoshifuma; Deng, Mario C.; Mancini, Donna.

In: Journal of Heart and Lung Transplantation, Vol. 28, No. 7, 07.2009, p. 667-669.

Research output: Contribution to journalArticle

Uriel, N, Jorde, UP, Cotarlan, V, Colombo, PC, Farr, M, Restaino, SW, Lietz, K, Naka, Y, Deng, MC & Mancini, D 2009, 'Heart Transplantation in Human Immunodeficiency Virus-Positive Patients', Journal of Heart and Lung Transplantation, vol. 28, no. 7, pp. 667-669. https://doi.org/10.1016/j.healun.2009.04.005
Uriel, Nir ; Jorde, Ulrich P. ; Cotarlan, Vlad ; Colombo, Paolo C. ; Farr, Maryjane ; Restaino, Susan W. ; Lietz, Katherine ; Naka, Yoshifuma ; Deng, Mario C. ; Mancini, Donna. / Heart Transplantation in Human Immunodeficiency Virus-Positive Patients. In: Journal of Heart and Lung Transplantation. 2009 ; Vol. 28, No. 7. pp. 667-669.
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