Heart Transplantation in Children With Down Syndrome

Justin Godown, Darlene Fountain, Neha Bansal, Rebecca Ameduri, Susan Anderson, Gary Beasley, Danielle Burstein, Kenneth Knecht, Kimberly Molina, Sherry Pye, Marc Richmond, Joseph A. Spinner, Kae Watanabe, Shawn West, Zdenka Reinhardt, Janet Scheel, Simon Urschel, Chet Villa, Seth A. Hollander

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

BACKGROUND: Children with Down syndrome (DS) have a high risk of cardiac disease that may prompt consideration for heart transplantation (HTx). However, transplantation in patients with DS is rarely reported. This project aimed to collect and describe waitlist and post– HTx outcomes in children with DS. METHODS AND RESULTS: This is a retrospective case series of children with DS listed for HTx. Pediatric HTx centers were identified by their participation in 2 international registries with centers reporting HTx in a patient with DS providing detailed demographic, medical, surgical, and posttransplant outcome data for analysis. A total of 26 patients with DS were listed for HTx from 1992 to 2020 (median age, 8.5 years; 46% male). High-risk or failed repair of congenital heart disease was the most common indication for transplant (N=18, 69%). A total of 23 (88%) patients survived to transplant. All transplanted patients survived to hospital discharge with a median posttransplant length of stay of 22 days. At a median posttransplant follow-up of 2.8 years, 20 (87%) patients were alive, 2 (9%) developed posttransplant lymphoproliferative disorder, and 8 (35%) were hospitalized for infection within the first year. Waitlist and posttransplant outcomes were similar in patients with and without DS (P=non-significant for all). CONCLUSIONS: Waitlist and post-HTx outcomes in children with DS selected for transplant listing are comparable to pediatric HTx recipients overall. Given acceptable outcomes, the presence of DS alone should not be considered an absolute contrain-dication to HTx.

Original languageEnglish (US)
Article numbere024883
JournalJournal of the American Heart Association
Volume11
Issue number10
DOIs
StatePublished - May 17 2022
Externally publishedYes

Keywords

  • Down syndrome
  • health disparities
  • heart transplantation
  • outcomes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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