Heart rate: A prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties

Daniela Dobre, Jeffrey S. Borer, Kim Fox, Karl Swedberg, Kirkwood F. Adams, John G.F. Cleland, Alain Cohen-Solal, Mihai Gheorghiade, Francois Gueyffier, Christopher M. O'Connor, Mona Fiuzat, Athul Patak, Ileana L. Piña, Giuseppe Rosano, Hani N. Sabbah, Luigi Tavazzi, Faiez Zannad

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbidities, and disease phenotype. Beneficial and harmful interactions may also exist. The aim of this paper is to summarize the current body of knowledge regarding the relevance of heart rate as a prognostic factor (risk marker) and particularly as a therapeutic target (riskfactor) in patients with chronic heart failure, with a special focus on ivabradine, a novel agent that is currently the only available purely bra-dycardic agent.

Original languageEnglish (US)
Pages (from-to)76-85
Number of pages10
JournalEuropean Journal of Heart Failure
Volume16
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • Amiodarone
  • Beta-blockers
  • Chronic heart failure
  • Digoxin
  • Heart rate
  • Heart rate-lowering drugs
  • Ivabradine
  • Verapamil

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Dobre, D., Borer, J. S., Fox, K., Swedberg, K., Adams, K. F., Cleland, J. G. F., Cohen-Solal, A., Gheorghiade, M., Gueyffier, F., O'Connor, C. M., Fiuzat, M., Patak, A., Piña, I. L., Rosano, G., Sabbah, H. N., Tavazzi, L., & Zannad, F. (2014). Heart rate: A prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties. European Journal of Heart Failure, 16(1), 76-85. https://doi.org/10.1093/eurjhf/hft129