Heart failure in diabetes

Stanislovas S. Jankauskas, Urna Kansakar, Fahimeh Varzideh, Scott Wilson, Pasquale Mone, Angela Lombardi, Jessica Gambardella, Gaetano Santulli

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management.

Original languageEnglish (US)
Article number154910
JournalMetabolism: Clinical and Experimental
StatePublished - Dec 2021


  • Adrenergic receptors
  • Aging
  • BHB
  • Bioenergetics
  • Cardiomyocytes
  • Cardiovascular endocrinology
  • Diabetes mellitus
  • Diabetic cardiomyopathy
  • Diastolic dysfunction
  • Endothelium
  • FOXO1
  • Fibroblasts
  • Fibrosis
  • HFpEF
  • Heart failure
  • Mitochondria
  • NADH
  • Oxidative stress
  • ROS
  • Senescence
  • T1DM
  • T2DM
  • VSMC

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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