Health-related quality of life of children with mild to moderate chronic kidney disease

Arlene C. Gerson, Alicia Wentz, Allison G. Abraham, Susan R. Mendley, Stephen R. Hooper, Robert W. Butler, Debbie S. Gipson, Marc B. Lande, Shlomo Shinnar, Marva M. Moxey-Mims, Bradley A. Warady, Susan L. Furth

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To compare the health-related quality of life (HRQoL) of children with chronic kidney disease (CKD) with healthy children; to evaluate the association between CKD severity and HRQoL; and to identity demographic, socioeconomic, and health-status variables that are associated with impairment in HRQoL in children with mild to moderate CKD. METHODS: This was a cross-sectional assessment of HRQoL in children who were aged 2 to 16 and had mild to moderate CKD using the Pediatric Inventory of Quality of Life Core Scales (PedsQL). Overall HRQoL and PedsQL domain means for parents and youth were compared with previously published norms by using independent sample t tests. Study participants were categorized by kidney disease stage (measured by iohexol-based glomerular filtration rate [iGFR]), and group differences in HRQoL were evaluated by using analysis of variance and Cuzick trend tests. The association between hypothesized predictors of HRQoL and PedsQL scores was evaluated with linear and logistic regression analyses. RESULTS: The study sample comprised 402 participants (mean age: 11 years, 60% male, 70% white, median iGFR: 42.5 mL/min per 1.73 m2, median CKD duration: 7 years). Youth with CKD had significantly lower physical, school, emotional, and social domain scores than healthy youth. iGFR was not associated with HRQoL. Longer disease duration and older age were associated with higher PedsQL scores in the domains of physical, emotional, and social functioning. Older age was associated with lower school domain scores. Maternal education ± 16 years was associated with higher PedsQL scores in the domains of physical, school, and social functioning. Short stature was associated with lower scores in the physical functioning domain. CONCLUSIONS: Children with mild to moderate CKD, in comparison with healthy children, reported poorer overall HRQoL and poorer physical, school, emotional, and social functioning. Early intervention to improve linear growth and to address school functioning difficulties is recommended.

Original languageEnglish (US)
JournalPediatrics
Volume125
Issue number2
DOIs
StatePublished - Feb 2010

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Chronic Renal Insufficiency
Quality of Life
Iohexol
Glomerular Filtration Rate
Kidney Diseases
Social Class
Health Status
Linear Models
Analysis of Variance
Parents
Logistic Models
Regression Analysis
Mothers
Demography
Pediatrics
Education
Equipment and Supplies
Growth

Keywords

  • HRQoL
  • Kidney disease
  • QoL
  • Short stature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Gerson, A. C., Wentz, A., Abraham, A. G., Mendley, S. R., Hooper, S. R., Butler, R. W., ... Furth, S. L. (2010). Health-related quality of life of children with mild to moderate chronic kidney disease. Pediatrics, 125(2). https://doi.org/10.1542/peds.2009-0085

Health-related quality of life of children with mild to moderate chronic kidney disease. / Gerson, Arlene C.; Wentz, Alicia; Abraham, Allison G.; Mendley, Susan R.; Hooper, Stephen R.; Butler, Robert W.; Gipson, Debbie S.; Lande, Marc B.; Shinnar, Shlomo; Moxey-Mims, Marva M.; Warady, Bradley A.; Furth, Susan L.

In: Pediatrics, Vol. 125, No. 2, 02.2010.

Research output: Contribution to journalArticle

Gerson, AC, Wentz, A, Abraham, AG, Mendley, SR, Hooper, SR, Butler, RW, Gipson, DS, Lande, MB, Shinnar, S, Moxey-Mims, MM, Warady, BA & Furth, SL 2010, 'Health-related quality of life of children with mild to moderate chronic kidney disease', Pediatrics, vol. 125, no. 2. https://doi.org/10.1542/peds.2009-0085
Gerson AC, Wentz A, Abraham AG, Mendley SR, Hooper SR, Butler RW et al. Health-related quality of life of children with mild to moderate chronic kidney disease. Pediatrics. 2010 Feb;125(2). https://doi.org/10.1542/peds.2009-0085
Gerson, Arlene C. ; Wentz, Alicia ; Abraham, Allison G. ; Mendley, Susan R. ; Hooper, Stephen R. ; Butler, Robert W. ; Gipson, Debbie S. ; Lande, Marc B. ; Shinnar, Shlomo ; Moxey-Mims, Marva M. ; Warady, Bradley A. ; Furth, Susan L. / Health-related quality of life of children with mild to moderate chronic kidney disease. In: Pediatrics. 2010 ; Vol. 125, No. 2.
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abstract = "OBJECTIVE: To compare the health-related quality of life (HRQoL) of children with chronic kidney disease (CKD) with healthy children; to evaluate the association between CKD severity and HRQoL; and to identity demographic, socioeconomic, and health-status variables that are associated with impairment in HRQoL in children with mild to moderate CKD. METHODS: This was a cross-sectional assessment of HRQoL in children who were aged 2 to 16 and had mild to moderate CKD using the Pediatric Inventory of Quality of Life Core Scales (PedsQL). Overall HRQoL and PedsQL domain means for parents and youth were compared with previously published norms by using independent sample t tests. Study participants were categorized by kidney disease stage (measured by iohexol-based glomerular filtration rate [iGFR]), and group differences in HRQoL were evaluated by using analysis of variance and Cuzick trend tests. The association between hypothesized predictors of HRQoL and PedsQL scores was evaluated with linear and logistic regression analyses. RESULTS: The study sample comprised 402 participants (mean age: 11 years, 60{\%} male, 70{\%} white, median iGFR: 42.5 mL/min per 1.73 m2, median CKD duration: 7 years). Youth with CKD had significantly lower physical, school, emotional, and social domain scores than healthy youth. iGFR was not associated with HRQoL. Longer disease duration and older age were associated with higher PedsQL scores in the domains of physical, emotional, and social functioning. Older age was associated with lower school domain scores. Maternal education ± 16 years was associated with higher PedsQL scores in the domains of physical, school, and social functioning. Short stature was associated with lower scores in the physical functioning domain. CONCLUSIONS: Children with mild to moderate CKD, in comparison with healthy children, reported poorer overall HRQoL and poorer physical, school, emotional, and social functioning. Early intervention to improve linear growth and to address school functioning difficulties is recommended.",
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AU - Butler, Robert W.

AU - Gipson, Debbie S.

AU - Lande, Marc B.

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