Health related quality of life in head and neck cancer treated with radiation therapy with or without chemotherapy

A systematic review

Jonathan H. Klein, Jonathan Livergant, Jolie Ringash

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

Health-related quality of life (HRQoL) is a subjective measure of patients' experience of disease and treatment. We systematically reviewed the literature to identify high quality manuscripts reporting HRQoL outcomes in adults with squamous cell carcinoma of the head and neck (HNSCC) treated with an organ-sparing curative regimen of radiation therapy with or without chemotherapy. Assessments were performed independently by two reviewers; a third reviewer resolved disputes. High quality reports were reviewed in detail to identify trends in HRQoL outcomes. MEDLINE and EMBASE searching yielded 276 distinct reports, plus 24 added via hand search. Of these, 53 met eligibility criteria and 18 were deemed high quality reports on the basis of a quality assessment tool. HRQoL declines after treatment but recovers to baseline levels, generally within 12 months. However, xerostomia-related HRQoL deficits may remain long-term. Combined chemoradiotherapy showed a trend toward worse HRQoL compared with RT alone. Intensity modulated radiotherapy (IMRT) yields better HRQoL compared with conventional or three-dimensional conformal radiotherapy. Baseline HRQoL may independently predict local-regional control and overall survival. Future research should incorporate HRQoL into phase III trials. However, adequate effort and journal space must be afforded to the HRQoL results of these studies to ensure proper reporting methods are followed, allowing clinicians to incorporate HRQoL into patient counseling and clinical decision making.

Original languageEnglish (US)
Pages (from-to)254-262
Number of pages9
JournalOral Oncology
Volume50
Issue number4
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Head and Neck Neoplasms
Radiotherapy
Quality of Life
Drug Therapy
Conformal Radiotherapy
Xerostomia
Intensity-Modulated Radiotherapy
Dissent and Disputes
Manuscripts
Chemoradiotherapy
MEDLINE
Counseling
Survival

Keywords

  • Chemoradiotherapy
  • Head and neck neoplasms
  • Quality of life
  • Questionnaires
  • Radiotherapy
  • Squamous cell carcinoma
  • Systematic reviews

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Health related quality of life in head and neck cancer treated with radiation therapy with or without chemotherapy : A systematic review. / Klein, Jonathan H.; Livergant, Jonathan; Ringash, Jolie.

In: Oral Oncology, Vol. 50, No. 4, 01.01.2014, p. 254-262.

Research output: Contribution to journalReview article

@article{e5e2072041db4fafbdc91cc35fde67c2,
title = "Health related quality of life in head and neck cancer treated with radiation therapy with or without chemotherapy: A systematic review",
abstract = "Health-related quality of life (HRQoL) is a subjective measure of patients' experience of disease and treatment. We systematically reviewed the literature to identify high quality manuscripts reporting HRQoL outcomes in adults with squamous cell carcinoma of the head and neck (HNSCC) treated with an organ-sparing curative regimen of radiation therapy with or without chemotherapy. Assessments were performed independently by two reviewers; a third reviewer resolved disputes. High quality reports were reviewed in detail to identify trends in HRQoL outcomes. MEDLINE and EMBASE searching yielded 276 distinct reports, plus 24 added via hand search. Of these, 53 met eligibility criteria and 18 were deemed high quality reports on the basis of a quality assessment tool. HRQoL declines after treatment but recovers to baseline levels, generally within 12 months. However, xerostomia-related HRQoL deficits may remain long-term. Combined chemoradiotherapy showed a trend toward worse HRQoL compared with RT alone. Intensity modulated radiotherapy (IMRT) yields better HRQoL compared with conventional or three-dimensional conformal radiotherapy. Baseline HRQoL may independently predict local-regional control and overall survival. Future research should incorporate HRQoL into phase III trials. However, adequate effort and journal space must be afforded to the HRQoL results of these studies to ensure proper reporting methods are followed, allowing clinicians to incorporate HRQoL into patient counseling and clinical decision making.",
keywords = "Chemoradiotherapy, Head and neck neoplasms, Quality of life, Questionnaires, Radiotherapy, Squamous cell carcinoma, Systematic reviews",
author = "Klein, {Jonathan H.} and Jonathan Livergant and Jolie Ringash",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.oraloncology.2014.01.015",
language = "English (US)",
volume = "50",
pages = "254--262",
journal = "Oral Oncology",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Health related quality of life in head and neck cancer treated with radiation therapy with or without chemotherapy

T2 - A systematic review

AU - Klein, Jonathan H.

AU - Livergant, Jonathan

AU - Ringash, Jolie

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Health-related quality of life (HRQoL) is a subjective measure of patients' experience of disease and treatment. We systematically reviewed the literature to identify high quality manuscripts reporting HRQoL outcomes in adults with squamous cell carcinoma of the head and neck (HNSCC) treated with an organ-sparing curative regimen of radiation therapy with or without chemotherapy. Assessments were performed independently by two reviewers; a third reviewer resolved disputes. High quality reports were reviewed in detail to identify trends in HRQoL outcomes. MEDLINE and EMBASE searching yielded 276 distinct reports, plus 24 added via hand search. Of these, 53 met eligibility criteria and 18 were deemed high quality reports on the basis of a quality assessment tool. HRQoL declines after treatment but recovers to baseline levels, generally within 12 months. However, xerostomia-related HRQoL deficits may remain long-term. Combined chemoradiotherapy showed a trend toward worse HRQoL compared with RT alone. Intensity modulated radiotherapy (IMRT) yields better HRQoL compared with conventional or three-dimensional conformal radiotherapy. Baseline HRQoL may independently predict local-regional control and overall survival. Future research should incorporate HRQoL into phase III trials. However, adequate effort and journal space must be afforded to the HRQoL results of these studies to ensure proper reporting methods are followed, allowing clinicians to incorporate HRQoL into patient counseling and clinical decision making.

AB - Health-related quality of life (HRQoL) is a subjective measure of patients' experience of disease and treatment. We systematically reviewed the literature to identify high quality manuscripts reporting HRQoL outcomes in adults with squamous cell carcinoma of the head and neck (HNSCC) treated with an organ-sparing curative regimen of radiation therapy with or without chemotherapy. Assessments were performed independently by two reviewers; a third reviewer resolved disputes. High quality reports were reviewed in detail to identify trends in HRQoL outcomes. MEDLINE and EMBASE searching yielded 276 distinct reports, plus 24 added via hand search. Of these, 53 met eligibility criteria and 18 were deemed high quality reports on the basis of a quality assessment tool. HRQoL declines after treatment but recovers to baseline levels, generally within 12 months. However, xerostomia-related HRQoL deficits may remain long-term. Combined chemoradiotherapy showed a trend toward worse HRQoL compared with RT alone. Intensity modulated radiotherapy (IMRT) yields better HRQoL compared with conventional or three-dimensional conformal radiotherapy. Baseline HRQoL may independently predict local-regional control and overall survival. Future research should incorporate HRQoL into phase III trials. However, adequate effort and journal space must be afforded to the HRQoL results of these studies to ensure proper reporting methods are followed, allowing clinicians to incorporate HRQoL into patient counseling and clinical decision making.

KW - Chemoradiotherapy

KW - Head and neck neoplasms

KW - Quality of life

KW - Questionnaires

KW - Radiotherapy

KW - Squamous cell carcinoma

KW - Systematic reviews

UR - http://www.scopus.com/inward/record.url?scp=84895466938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895466938&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2014.01.015

DO - 10.1016/j.oraloncology.2014.01.015

M3 - Review article

VL - 50

SP - 254

EP - 262

JO - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

IS - 4

ER -