Headache in thrombotic thrombocytopenic purpura: Two cases with pathophysiological considerations

David Bezov, Richard B. Lipton, Nikolai Podoltsev, Chi G. Zhao, Sait Ashina

Research output: Contribution to journalArticle

1 Scopus citations


Headache is one of the most common neurological symptoms reported by patients with thrombotic thrombocytopenic purpura (TTP). Reports of headache characteristics in patients with TTP are rare. We report 2 cases of headache in a setting of TTP and review previous reports. Headache in TTP can have features in common with both migraine and tension-type headache. Although the pathophysiology of headache in TTP is not certain, platelet aggregation and activation may play a key role.

Original languageEnglish (US)
Pages (from-to)1060-1064
Number of pages5
Issue number6
StatePublished - Jun 2010



  • Headache
  • Headache characteristics
  • Platelet activation
  • Platelet aggregation
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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