Headache in thrombotic thrombocytopenic purpura: Two cases with pathophysiological considerations

David Bezov; Richard B. Lipton; Nikolai Podoltsev; Chi G. Zhao; Sait Ashina

doi:10.1111/j.1526-4610.2010.01680.x

Headache in thrombotic thrombocytopenic purpura: Two cases with pathophysiological considerations

David Bezov, Richard B. Lipton, Nikolai Podoltsev, Chi G. Zhao, Sait Ashina

Neurology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Headache is one of the most common neurological symptoms reported by patients with thrombotic thrombocytopenic purpura (TTP). Reports of headache characteristics in patients with TTP are rare. We report 2 cases of headache in a setting of TTP and review previous reports. Headache in TTP can have features in common with both migraine and tension-type headache. Although the pathophysiology of headache in TTP is not certain, platelet aggregation and activation may play a key role.

Original language	English (US)
Pages (from-to)	1060-1064
Number of pages	5
Journal	Headache
Volume	50
Issue number	6
DOIs	https://doi.org/10.1111/j.1526-4610.2010.01680.x
State	Published - Jun 2010

Keywords

Headache
Headache characteristics
Platelet activation
Platelet aggregation
Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1526-4610.2010.01680.x

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abstract = "Headache is one of the most common neurological symptoms reported by patients with thrombotic thrombocytopenic purpura (TTP). Reports of headache characteristics in patients with TTP are rare. We report 2 cases of headache in a setting of TTP and review previous reports. Headache in TTP can have features in common with both migraine and tension-type headache. Although the pathophysiology of headache in TTP is not certain, platelet aggregation and activation may play a key role.",

keywords = "Headache, Headache characteristics, Platelet activation, Platelet aggregation, Thrombotic thrombocytopenic purpura",

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AU - Podoltsev, Nikolai

AU - Zhao, Chi G.

AU - Ashina, Sait

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AB - Headache is one of the most common neurological symptoms reported by patients with thrombotic thrombocytopenic purpura (TTP). Reports of headache characteristics in patients with TTP are rare. We report 2 cases of headache in a setting of TTP and review previous reports. Headache in TTP can have features in common with both migraine and tension-type headache. Although the pathophysiology of headache in TTP is not certain, platelet aggregation and activation may play a key role.

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KW - Platelet aggregation

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Headache in thrombotic thrombocytopenic purpura: Two cases with pathophysiological considerations

Abstract

Keywords

ASJC Scopus subject areas

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