Headache characteristics in hospitalized patients with Lyme disease

S. N. Scelsa, R. B. Lipton, Steven Herskovitz, S. Herskovitz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We reviewed 49 patients consecutively hospitalized for neurologic Lyme disease to determine the frequency and characteristics of recent onset headaches in this group. All patients had positive serum Lyme ELISAs and other neurologic illness excluded. Recent-onset headache occurred in 26 of 49 patients (53%). Patients with headaches more commonly had central nervous system involvement (54% vs 19%, P<.05) and flu-like illness (58% vs 19%, P<.0005). Eight of 26 (31%) met criteria for meningitis or encephalitis with abnormal CSF examinations. All 8 had focal findings (6), cognitive dysfunction (1), or both (1). The remaining 18 patients had recent onset headaches resembling migraine (9), tension-type headache (5), or neither (4). Antibiotic treatment resulted in complete headache resolution in 11 of 14 patients with available follow-up data. Based on these findings, we conclude that recent-onset headaches are common in patients hospitalized with Lyme disease. Of those with meningitis or encephalitis requiring intravenous antibiotics, all had focal neurologic findings or cognitive abnormalities, not just headaches.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalHeadache
Volume35
Issue number3
StatePublished - 1995
Externally publishedYes

Fingerprint

Lyme Disease
Headache
Encephalitis
Meningitis
Lyme Neuroborreliosis
Anti-Bacterial Agents
Tension-Type Headache
Neurologic Manifestations
Migraine Disorders
Nervous System
Central Nervous System
Enzyme-Linked Immunosorbent Assay
Serum

Keywords

  • encephalitis
  • headache
  • Lyme borreliosis
  • Lyme disease
  • meningitis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Scelsa, S. N., Lipton, R. B., Herskovitz, S., & Herskovitz, S. (1995). Headache characteristics in hospitalized patients with Lyme disease. Headache, 35(3), 125-130.

Headache characteristics in hospitalized patients with Lyme disease. / Scelsa, S. N.; Lipton, R. B.; Herskovitz, Steven; Herskovitz, S.

In: Headache, Vol. 35, No. 3, 1995, p. 125-130.

Research output: Contribution to journalArticle

Scelsa, SN, Lipton, RB, Herskovitz, S & Herskovitz, S 1995, 'Headache characteristics in hospitalized patients with Lyme disease', Headache, vol. 35, no. 3, pp. 125-130.
Scelsa, S. N. ; Lipton, R. B. ; Herskovitz, Steven ; Herskovitz, S. / Headache characteristics in hospitalized patients with Lyme disease. In: Headache. 1995 ; Vol. 35, No. 3. pp. 125-130.
@article{2d0e3007162a45d0a39aea331577cba2,
title = "Headache characteristics in hospitalized patients with Lyme disease",
abstract = "We reviewed 49 patients consecutively hospitalized for neurologic Lyme disease to determine the frequency and characteristics of recent onset headaches in this group. All patients had positive serum Lyme ELISAs and other neurologic illness excluded. Recent-onset headache occurred in 26 of 49 patients (53{\%}). Patients with headaches more commonly had central nervous system involvement (54{\%} vs 19{\%}, P<.05) and flu-like illness (58{\%} vs 19{\%}, P<.0005). Eight of 26 (31{\%}) met criteria for meningitis or encephalitis with abnormal CSF examinations. All 8 had focal findings (6), cognitive dysfunction (1), or both (1). The remaining 18 patients had recent onset headaches resembling migraine (9), tension-type headache (5), or neither (4). Antibiotic treatment resulted in complete headache resolution in 11 of 14 patients with available follow-up data. Based on these findings, we conclude that recent-onset headaches are common in patients hospitalized with Lyme disease. Of those with meningitis or encephalitis requiring intravenous antibiotics, all had focal neurologic findings or cognitive abnormalities, not just headaches.",
keywords = "encephalitis, headache, Lyme borreliosis, Lyme disease, meningitis",
author = "Scelsa, {S. N.} and Lipton, {R. B.} and Steven Herskovitz and S. Herskovitz",
year = "1995",
language = "English (US)",
volume = "35",
pages = "125--130",
journal = "Headache",
issn = "0017-8748",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Headache characteristics in hospitalized patients with Lyme disease

AU - Scelsa, S. N.

AU - Lipton, R. B.

AU - Herskovitz, Steven

AU - Herskovitz, S.

PY - 1995

Y1 - 1995

N2 - We reviewed 49 patients consecutively hospitalized for neurologic Lyme disease to determine the frequency and characteristics of recent onset headaches in this group. All patients had positive serum Lyme ELISAs and other neurologic illness excluded. Recent-onset headache occurred in 26 of 49 patients (53%). Patients with headaches more commonly had central nervous system involvement (54% vs 19%, P<.05) and flu-like illness (58% vs 19%, P<.0005). Eight of 26 (31%) met criteria for meningitis or encephalitis with abnormal CSF examinations. All 8 had focal findings (6), cognitive dysfunction (1), or both (1). The remaining 18 patients had recent onset headaches resembling migraine (9), tension-type headache (5), or neither (4). Antibiotic treatment resulted in complete headache resolution in 11 of 14 patients with available follow-up data. Based on these findings, we conclude that recent-onset headaches are common in patients hospitalized with Lyme disease. Of those with meningitis or encephalitis requiring intravenous antibiotics, all had focal neurologic findings or cognitive abnormalities, not just headaches.

AB - We reviewed 49 patients consecutively hospitalized for neurologic Lyme disease to determine the frequency and characteristics of recent onset headaches in this group. All patients had positive serum Lyme ELISAs and other neurologic illness excluded. Recent-onset headache occurred in 26 of 49 patients (53%). Patients with headaches more commonly had central nervous system involvement (54% vs 19%, P<.05) and flu-like illness (58% vs 19%, P<.0005). Eight of 26 (31%) met criteria for meningitis or encephalitis with abnormal CSF examinations. All 8 had focal findings (6), cognitive dysfunction (1), or both (1). The remaining 18 patients had recent onset headaches resembling migraine (9), tension-type headache (5), or neither (4). Antibiotic treatment resulted in complete headache resolution in 11 of 14 patients with available follow-up data. Based on these findings, we conclude that recent-onset headaches are common in patients hospitalized with Lyme disease. Of those with meningitis or encephalitis requiring intravenous antibiotics, all had focal neurologic findings or cognitive abnormalities, not just headaches.

KW - encephalitis

KW - headache

KW - Lyme borreliosis

KW - Lyme disease

KW - meningitis

UR - http://www.scopus.com/inward/record.url?scp=0028915501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028915501&partnerID=8YFLogxK

M3 - Article

C2 - 7721571

AN - SCOPUS:0028915501

VL - 35

SP - 125

EP - 130

JO - Headache

JF - Headache

SN - 0017-8748

IS - 3

ER -