Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene

Larisa V. Debelenko, Michael R. Emmert-Buck, Pachiappan Manickam, Marybeth Kester, Siradanahalli C. Guru, Estela M. DiFranco, Shodimu Emmanuel Olufemi, Sunita Agarwal, Irina A. Lubensky, Zhengping Zhuang, A. Lee Burns, Allen M. Spiegel, Lance A. Liotta, Francis S. Collins, Stephen J. Marx, Settara C. Chandrasekharappa

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by development of multiple endocrine tumors in affected individuals. The gene responsible for the disease has been mapped to chromosome 11q13 by linkage analysis, but the gene itself has not yet been identified. We allelotyped 33 affected individuals from an extensive MEN1 kindred using eight polymorphic markers located on chromosome 11q13, including two new markers (D11S4907 and D11S4908) that we derived and mapped to the SEA-D11S913 region. Analysis of affected individuals revealed two separate recombination events, providing new centromeric and telomeric boundaries for the MEN1 gene. The present data indicate the MEN1 gene is located between markers D11S1883 and D11S4907, an approximate 2 Mb region on chromosome 11q13.

Original languageEnglish (US)
Pages (from-to)1039-1042
Number of pages4
JournalCancer Research
Volume57
Issue number6
StatePublished - Apr 9 1997
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Debelenko, L. V., Emmert-Buck, M. R., Manickam, P., Kester, M., Guru, S. C., DiFranco, E. M., Olufemi, S. E., Agarwal, S., Lubensky, I. A., Zhuang, Z., Lee Burns, A., Spiegel, A. M., Liotta, L. A., Collins, F. S., Marx, S. J., & Chandrasekharappa, S. C. (1997). Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene. Cancer Research, 57(6), 1039-1042.