Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene

Larisa V. Debelenko; Michael R. Emmert-Buck; Pachiappan Manickam; Marybeth Kester; Siradanahalli C. Guru; Estela M. DiFranco; Shodimu Emmanuel Olufemi; Sunita Agarwal; Irina A. Lubensky; Zhengping Zhuang; A. Lee Burns; Allen M. Spiegel; Lance A. Liotta; Francis S. Collins; Stephen J. Marx; Settara C. Chandrasekharappa

Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene

Larisa V. Debelenko, Michael R. Emmert-Buck, Pachiappan Manickam, Marybeth Kester, Siradanahalli C. Guru, Estela M. DiFranco, Shodimu Emmanuel Olufemi, Sunita Agarwal, Irina A. Lubensky, Zhengping Zhuang, A. Lee Burns, Allen M. Spiegel, Lance A. Liotta, Francis S. Collins, Stephen J. Marx, Settara C. Chandrasekharappa

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by development of multiple endocrine tumors in affected individuals. The gene responsible for the disease has been mapped to chromosome 11q13 by linkage analysis, but the gene itself has not yet been identified. We allelotyped 33 affected individuals from an extensive MEN1 kindred using eight polymorphic markers located on chromosome 11q13, including two new markers (D11S4907 and D11S4908) that we derived and mapped to the SEA-D11S913 region. Analysis of affected individuals revealed two separate recombination events, providing new centromeric and telomeric boundaries for the MEN1 gene. The present data indicate the MEN1 gene is located between markers D11S1883 and D11S4907, an approximate 2 Mb region on chromosome 11q13.

Original language	English (US)
Pages (from-to)	1039-1042
Number of pages	4
Journal	Cancer Research
Volume	57
Issue number	6
State	Published - Apr 9 1997
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Debelenko, L. V., Emmert-Buck, M. R., Manickam, P., Kester, M., Guru, S. C., DiFranco, E. M., Olufemi, S. E., Agarwal, S., Lubensky, I. A., Zhuang, Z., Lee Burns, A., Spiegel, A. M., Liotta, L. A., Collins, F. S., Marx, S. J., & Chandrasekharappa, S. C. (1997). Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene. Cancer Research, 57(6), 1039-1042.

Debelenko, LV, Emmert-Buck, MR, Manickam, P, Kester, M, Guru, SC, DiFranco, EM, Olufemi, SE, Agarwal, S, Lubensky, IA, Zhuang, Z, Lee Burns, A, Spiegel, AM, Liotta, LA, Collins, FS, Marx, SJ & Chandrasekharappa, SC 1997, 'Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene', Cancer Research, vol. 57, no. 6, pp. 1039-1042.

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title = "Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene",

abstract = "Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by development of multiple endocrine tumors in affected individuals. The gene responsible for the disease has been mapped to chromosome 11q13 by linkage analysis, but the gene itself has not yet been identified. We allelotyped 33 affected individuals from an extensive MEN1 kindred using eight polymorphic markers located on chromosome 11q13, including two new markers (D11S4907 and D11S4908) that we derived and mapped to the SEA-D11S913 region. Analysis of affected individuals revealed two separate recombination events, providing new centromeric and telomeric boundaries for the MEN1 gene. The present data indicate the MEN1 gene is located between markers D11S1883 and D11S4907, an approximate 2 Mb region on chromosome 11q13.",

author = "Debelenko, {Larisa V.} and Emmert-Buck, {Michael R.} and Pachiappan Manickam and Marybeth Kester and Guru, {Siradanahalli C.} and DiFranco, {Estela M.} and Olufemi, {Shodimu Emmanuel} and Sunita Agarwal and Lubensky, {Irina A.} and Zhengping Zhuang and {Lee Burns}, A. and Spiegel, {Allen M.} and Liotta, {Lance A.} and Collins, {Francis S.} and Marx, {Stephen J.} and Chandrasekharappa, {Settara C.}",

year = "1997",

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AU - Kester, Marybeth

AU - Guru, Siradanahalli C.

AU - DiFranco, Estela M.

AU - Olufemi, Shodimu Emmanuel

AU - Agarwal, Sunita

AU - Lubensky, Irina A.

AU - Zhuang, Zhengping

AU - Lee Burns, A.

AU - Spiegel, Allen M.

AU - Liotta, Lance A.

AU - Collins, Francis S.

AU - Marx, Stephen J.

AU - Chandrasekharappa, Settara C.

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AB - Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by development of multiple endocrine tumors in affected individuals. The gene responsible for the disease has been mapped to chromosome 11q13 by linkage analysis, but the gene itself has not yet been identified. We allelotyped 33 affected individuals from an extensive MEN1 kindred using eight polymorphic markers located on chromosome 11q13, including two new markers (D11S4907 and D11S4908) that we derived and mapped to the SEA-D11S913 region. Analysis of affected individuals revealed two separate recombination events, providing new centromeric and telomeric boundaries for the MEN1 gene. The present data indicate the MEN1 gene is located between markers D11S1883 and D11S4907, an approximate 2 Mb region on chromosome 11q13.

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Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene

Abstract

ASJC Scopus subject areas

UN SDGs

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