Abstract
We report the synthesis and evaluation of 5-halogenated-1,2,3-Triazoles as inhibitors of biotin protein ligase from Staphylococcus aureus. The halogenated compounds exhibit significantly improved antibacterial activity over their nonhalogenated counterparts. Importantly, the 5-fluoro-1,2,3-Triazole compound 4c displays antibacterial activity against S. aureus ATCC49775 with a minimum inhibitory concentration (MIC) of 8 μg/mL.
Original language | English (US) |
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Pages (from-to) | 175-184 |
Number of pages | 10 |
Journal | ACS Infectious Diseases |
Volume | 4 |
Issue number | 2 |
DOIs | |
State | Published - Feb 9 2018 |
Keywords
- Staphylococcus aureus
- antibiotic
- biotin protein ligase
- enzyme inhibitor
ASJC Scopus subject areas
- Infectious Diseases