H1, a novel derivative of tetrandrine reverse P-glycoprotein-mediated multidrug resistance by inhibiting transport function and expression of P-glycoprotein

Medicine & Life Sciences

• tetrandrine 100%
• ATP Binding Cassette Transporter, Subfamily B, Member 1 70%
• Multiple Drug Resistance 66%
• Ubiquitination 9%
• MCF-7 Cells 9%
• Adenosine Triphosphatases 9%
• P-glycoprotein 2 6%
• Rhodamine 123 6%
• MAP Kinase Signaling System 5%
• Immunoprecipitation 4%
• RNA Interference 4%
• Doxorubicin 4%
• Half-Life 4%
• Signal Transduction 3%
• Flow Cytometry 3%
• Down-Regulation 3%
• Western Blotting 3%
• Cell Line 2%
• Polymerase Chain Reaction 2%
• Proteins 1%

Chemical Compounds

• Rhodamine 123 47%
• Resistance 40%
• Cytometry 33%
• Doxorubicin 33%
• Reaction Half Life 30%
• Flow 20%
• Protein 13%