H-Y Antigen in a 46, XX Female with Dysgenetic Ovaries

Bruce Shickmanter, Stephen Wachtel, Linda Cahill, Jeffrey Ross, Michael Shreefter, Enoch Booth, Robert E. Scully

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Hypogonadism secondary to ovarian dysgenesis or resistant ovary syndrome was diagnosed in a 19-yr-old obese woman with primary amenorrhea, a 46.XX karyotype, and an H-Y+ cellular phenotype. Small ovoid gonads (1.5 × 0.6 cm) were found bilaterally; these were encased in a dense venous network. The stroma was ovarian, and primordial follicles and some primary follicles were present, but there were no follicles at or beyond the antrum stage. There was no evidence of testicular tissue and no evidence of malignancy. Analysis of serological data indicated the possibility of residual H-Y antigen in the blood cells of the mother.

Original languageEnglish (US)
Pages (from-to)1042-1046
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume60
Issue number5
DOIs
StatePublished - May 1985
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Shickmanter, B., Wachtel, S., Cahill, L., Ross, J., Shreefter, M., Booth, E., & Scully, R. E. (1985). H-Y Antigen in a 46, XX Female with Dysgenetic Ovaries. Journal of Clinical Endocrinology and Metabolism, 60(5), 1042-1046. https://doi.org/10.1210/jcem-60-5-1042