Gynaecologic effects of Tamoxifen

Dennis Yi Shin Kuo, Carolyn D. Runowicz

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Tamoxifen, an estrogen antagonist, is widely used as adjuvant therapy in patients with breast cancer. Its efficacy in increasing survival and reducing recurrence rates has been demonstrated in several European and American studies. However, its effects appear to be tissue specific. Tamoxifen exerts an estrogen effect (agonist) on the endometrium, myometrium and vagina. An increase in uterine cancer has been confirmed in several placebo-controlled clinical trials. Due to the widespread use of this drug, it is timely to review the gynecologic effects of tamoxifen.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalMedical Oncology
Volume12
Issue number2
DOIs
StatePublished - Jun 1 1995

Keywords

  • breast cancer
  • estrogen effect
  • tamoxifen
  • uterine cancer

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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