Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression

Gary J. Schwartz, Cynthia F. Salorio, Chris Skoglund, Timothy H. Moran

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Subdiaphragmatic vagal afferent (SVA) signals arising from gut sites may provide critical feedback for the control of food intake within a meal. To evaluate the role of SVAs in both spontaneous and scheduled meals, food intake was assessed in two paradigms in male Sprague-Dawley rats. In the first study, control (Con) rats (n = 6) and rats with subdiaphragmatic vagal deafferentation (SDA) (n = 7) had 12-h nightly access to Ensure liquid diet (1 kcal/ml). SDA rats had larger and fewer meals and maintained initial rapid rates of licking, yet total numbers of licks were unaffected. In the second study, Con (n = 8) and SDA (n = 7) rats had scheduled access to 12.5% liquid glucose after overnight food deprivation. Glucose intake was assessed after 5-ml gastric preloads of 0.9% saline or glucose, peptone, and Intralipid solutions at three concentrations (0.5, 1, and 2 kcal/ml). Glucose and peptone preloads suppressed intake similarly in Con and SDA rats, whereas Intralipid was ineffective. These results suggest that meal-related SVA signals 1) are not critical in determining preload-induced feeding suppression after deprivation, yet 2) contribute to satiety during spontaneous meals.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume276
Issue number6 45-6
StatePublished - Jun 1999
Externally publishedYes

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Meals
Stomach
Glucose
Peptones
Eating
Food Deprivation
Sprague Dawley Rats
Diet
phospholipid emulsion soybean oil

Keywords

  • Brain-gut communication
  • Food intake
  • Ingestive behavior
  • Visceral afferents

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression. / Schwartz, Gary J.; Salorio, Cynthia F.; Skoglund, Chris; Moran, Timothy H.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 276, No. 6 45-6, 06.1999.

Research output: Contribution to journalArticle

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