TY - JOUR
T1 - Gut Microbiota and Short Chain Fatty Acids
T2 - Implications in Glucose Homeostasis
AU - Portincasa, Piero
AU - Bonfrate, Leonilde
AU - Vacca, Mirco
AU - De Angelis, Maria
AU - Farella, Ilaria
AU - Lanza, Elisa
AU - Khalil, Mohamad
AU - Wang, David Q.H.
AU - Sperandio, Markus
AU - Di Ciaula, Agostino
N1 - Funding Information:
Funding: The present paper is written in the context of the project FOIE GRAS where P.P. has received funding from the European Union’s Horizon 2020 Research and Innovation program under the Marie Sklodowska-Curie Grant Agreement No. 722619. P.P. and M.D.A. are recipient of grant FEVER APULIAE from Region Apulia (Rare Diseases—all’art. 6 della l.r. n. 15 del 2018), 2019.
Funding Information:
The present paper is written in the context of the project FOIE GRAS where P.P. has received funding from the European Union?s Horizon 2020 Research and Innovation program under the Marie Sklodowska-Curie Grant Agreement No. 722619. P.P. and M.D.A. are recipient of grant FEVER APULIAE from Region Apulia (Rare Diseases?all?art. 6 della l.r. n. 15 del 2018), 2019.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Gut microbiota encompasses a wide variety of commensal microorganisms consisting of trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host, and related metabolites have profound effects on human health. In this respect, gut microbiota plays a pivotal role in the regulation of metabolic, endocrine, and immune functions. Bacterial metabolites include the short chain fatty acids (SCFAs) acetate (C2), propionate (C3), and butyrate (C4), which are the most abundant SCFAs in the human body and the most abundant anions in the colon. SCFAs are made from fermentation of dietary fiber and resistant starch in the gut. They modulate several metabolic pathways and are involved in obesity, insulin resistance, and type 2 diabetes. Thus, diet might influence gut microbiota composition and activity, SCFAs production, and metabolic effects. In this narrative review, we discuss the relevant research focusing on the relationship between gut microbiota, SCFAs, and glucose metabolism.
AB - Gut microbiota encompasses a wide variety of commensal microorganisms consisting of trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host, and related metabolites have profound effects on human health. In this respect, gut microbiota plays a pivotal role in the regulation of metabolic, endocrine, and immune functions. Bacterial metabolites include the short chain fatty acids (SCFAs) acetate (C2), propionate (C3), and butyrate (C4), which are the most abundant SCFAs in the human body and the most abundant anions in the colon. SCFAs are made from fermentation of dietary fiber and resistant starch in the gut. They modulate several metabolic pathways and are involved in obesity, insulin resistance, and type 2 diabetes. Thus, diet might influence gut microbiota composition and activity, SCFAs production, and metabolic effects. In this narrative review, we discuss the relevant research focusing on the relationship between gut microbiota, SCFAs, and glucose metabolism.
KW - Bacteria
KW - Diet
KW - Fiber
KW - Glucose homeostasis
KW - Intestine
KW - Metabolome
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U2 - 10.3390/ijms23031105
DO - 10.3390/ijms23031105
M3 - Review article
C2 - 35163038
AN - SCOPUS:85122924457
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 3
M1 - 1105
ER -
