@article{0dd7237aceb44ac08e889a1897b06a2a,
title = "Gut microbial-related choline metabolite trimethylamine-N-oxide is associated with progression of carotid artery atherosclerosis in HIV infection",
abstract = "We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.",
keywords = "Carotid atherosclerosis, Choline metabolites, HIV infection, Risk factors, Trimethylamine-N-oxide",
author = "Zhilei Shan and Clish, {Clary B.} and Simin Hua and Scott, {Justin M.} and Hanna, {David B.} and Burk, {Robert D.} and Haberlen, {Sabina A.} and Shah, {Sanjiv J.} and Margolick, {Joseph B.} and Sears, {Cynthia L.} and Post, {Wendy S.} and Landay, {Alan L.} and Lazar, {Jason M.} and Hodis, {Howard N.} and Kathryn Anastos and Kaplan, {Robert C.} and Qibin Qi",
note = "Funding Information: This work was supported by the National Heart, Lung, and Blood Institute (grant numbers K01HL129892 and R01HL140976 to Q. Q.; R01 HL126543, R01 HL132794, R01HL083760, R01HL095140 to R. C. K.; R01HL095129 to W. S. P.; and K01HL137557 to D. B. H.); and Feldstein Medical Foundation research grant to Q. Q. The WIHS is supported by the National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Cancer Institute (NCI), the National Institute on Drug Abuse, and the National Institute on Mental Health. Targeted supplemental funding is also provided by the National Institute of Dental and Craniofacial Research, the National Institute on Alcohol Abuse and Alcoholism, the National Institute on Deafness and other Communication Disorders, and the NIH Office of Research on Women's Health. WIHS data collection is also supported by University of Southern California Clinical and Translational Science Award (grant number UL1-TR000004), Atlanta Clinical and Translational Science Award (grant number UL1-TR000454), and University of North Carolina Center for AIDS Research (grant number P30-AI-050410). The MACS is supported by the NIAID and NCI. MACS data collection is also supported by Johns Hopkins University Clinical and Translational Science Award (grant number UL1-TR000424). Funding Information: Financial support. This work was supported by the National Heart, Lung, and Blood Institute (grant numbers K01HL129892 and R01HL140976 to Q. Q.; R01 HL126543, R01 HL132794, R01HL083760, R01HL095140 to R. C. K.; R01HL095129 to W. S. P.; and K01HL137557 to D. B. H.); and Feldstein Medical Foundation research grant to Q. Q. The WIHS is supported by the National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Cancer Institute (NCI), the National Institute on Drug Abuse, and the National Institute on Mental Health. Targeted supplemental funding is also provided by the National Institute of Dental and Craniofacial Research, the National Institute on Alcohol Abuse and Alcoholism, the National Institute on Deafness and other Communication Disorders, and the NIH Office of Research on Women{\textquoteright}s Health. WIHS data collection is also supported by University of Southern California Clinical and Translational Science Award (grant number UL1-TR000004), Atlanta Clinical and Translational Science Award (grant number UL1-TR000454), and University of North Carolina Center for AIDS Research (grant number P30-AI-050410). The MACS is supported by the NIAID and NCI. MACS data collection is also supported by Johns Hopkins University Clinical and Translational Science Award (grant number UL1-TR000424). Publisher Copyright: {\textcopyright} The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.",
year = "2018",
month = sep,
day = "22",
doi = "10.1093/infdis/jiy356",
language = "English (US)",
volume = "218",
pages = "1474--1479",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "9",
}
