Gut microbial-related choline metabolite trimethylamine-N-oxide is associated with progression of carotid artery atherosclerosis in HIV infection

Zhilei Shan, Clary B. Clish, Simin Hua, Justin M. Scott, David B. Hanna, Robert D. Burk, Sabina A. Haberlen, Sanjiv J. Shah, Joseph B. Margolick, Cynthia L. Sears, Wendy S. Post, Alan L. Landay, Jason M. Lazar, Howard N. Hodis, Kathryn Anastos, Robert C. Kaplan, Qibin Qi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.

Original languageEnglish (US)
Pages (from-to)1474-1479
Number of pages6
JournalJournal of Infectious Diseases
Volume218
Issue number9
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Carotid atherosclerosis
  • Choline metabolites
  • HIV infection
  • Risk factors
  • Trimethylamine-N-oxide

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Shan, Z., Clish, C. B., Hua, S., Scott, J. M., Hanna, D. B., Burk, R. D., Haberlen, S. A., Shah, S. J., Margolick, J. B., Sears, C. L., Post, W. S., Landay, A. L., Lazar, J. M., Hodis, H. N., Anastos, K., Kaplan, R. C., & Qi, Q. (2018). Gut microbial-related choline metabolite trimethylamine-N-oxide is associated with progression of carotid artery atherosclerosis in HIV infection. Journal of Infectious Diseases, 218(9), 1474-1479. https://doi.org/10.1093/infdis/jiy356