Gustatory neural responses in the medial orbitofrontal cortex of the old world monkey

Thomas C. Pritchard, Erin M. Edwards, Carrie A. Smith, Kristen G. Hilgert, Andrew M. Gavlick, Thomas D. Maryniak, Gary J. Schwartz, Thomas R. Scott

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The primary taste cortex has widespread and occasionally dense projections to the orbitofrontal cortex (OFC) in the macaque. Nonetheless, electrophysiological studies have revealed that only 2-8% of the cells in the OFC are activated by taste stimuli on the tongue. We describe an area centered in Brodmann's area 13m of the medial OFC (mOFC) where taste neurons are more concentrated. It consists of a 12 mm2 core, where gustatory neurons constituted 20% of the population, and a 1 mm perimeter in which 8% of the cells responded to taste. Data were collected from three awake cynomolgus monkeys (Macaco fascicularis) prepared for chronic recording. Single neurons were isolated with epoxylite-coated tungsten microelectrodes and tested for responsiveness to 1.0 M glucose, 0.3 M NaCl, 0.03 M HCl, and 0.001 M QHCl. These stimuli elicited responses that were 96% excitatory and ranged from 5.2 to 5.9 spikes/s. Cells were broadly tuned (H = 0.79), similar to those in the anterior insula (H = 0.70), and decidedly unlike the narrowly tuned taste neurons in the caudolateral OFC (clOFC; H = 0.39). Whereas 82% of the taste cells in the clOFC respond to glucose, in the mOFC, HCl-responsive (56%), glucose-responsive (50%), NaCl-responsive (43%), and QHCl-responsive (40%) cells were almost evenly represented. The mOFC taste area appears to comprise a major gustatory relay that lies anatomically and functionally between the anterior insula and the clOFC.

Original languageEnglish (US)
Pages (from-to)6047-6056
Number of pages10
JournalJournal of Neuroscience
Volume25
Issue number26
DOIs
StatePublished - Jun 29 2005

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Cercopithecidae
Prefrontal Cortex
Neurons
Glucose
Tungsten
Macaca fascicularis
Macaca
Microelectrodes
Tongue

Keywords

  • Coding
  • Cortex
  • Macaque
  • Neurophysiology
  • Orbitofrontal
  • Taste

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pritchard, T. C., Edwards, E. M., Smith, C. A., Hilgert, K. G., Gavlick, A. M., Maryniak, T. D., ... Scott, T. R. (2005). Gustatory neural responses in the medial orbitofrontal cortex of the old world monkey. Journal of Neuroscience, 25(26), 6047-6056. https://doi.org/10.1523/JNEUROSCI.0430-05.2005

Gustatory neural responses in the medial orbitofrontal cortex of the old world monkey. / Pritchard, Thomas C.; Edwards, Erin M.; Smith, Carrie A.; Hilgert, Kristen G.; Gavlick, Andrew M.; Maryniak, Thomas D.; Schwartz, Gary J.; Scott, Thomas R.

In: Journal of Neuroscience, Vol. 25, No. 26, 29.06.2005, p. 6047-6056.

Research output: Contribution to journalArticle

Pritchard, TC, Edwards, EM, Smith, CA, Hilgert, KG, Gavlick, AM, Maryniak, TD, Schwartz, GJ & Scott, TR 2005, 'Gustatory neural responses in the medial orbitofrontal cortex of the old world monkey', Journal of Neuroscience, vol. 25, no. 26, pp. 6047-6056. https://doi.org/10.1523/JNEUROSCI.0430-05.2005
Pritchard TC, Edwards EM, Smith CA, Hilgert KG, Gavlick AM, Maryniak TD et al. Gustatory neural responses in the medial orbitofrontal cortex of the old world monkey. Journal of Neuroscience. 2005 Jun 29;25(26):6047-6056. https://doi.org/10.1523/JNEUROSCI.0430-05.2005
Pritchard, Thomas C. ; Edwards, Erin M. ; Smith, Carrie A. ; Hilgert, Kristen G. ; Gavlick, Andrew M. ; Maryniak, Thomas D. ; Schwartz, Gary J. ; Scott, Thomas R. / Gustatory neural responses in the medial orbitofrontal cortex of the old world monkey. In: Journal of Neuroscience. 2005 ; Vol. 25, No. 26. pp. 6047-6056.
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abstract = "The primary taste cortex has widespread and occasionally dense projections to the orbitofrontal cortex (OFC) in the macaque. Nonetheless, electrophysiological studies have revealed that only 2-8{\%} of the cells in the OFC are activated by taste stimuli on the tongue. We describe an area centered in Brodmann's area 13m of the medial OFC (mOFC) where taste neurons are more concentrated. It consists of a 12 mm2 core, where gustatory neurons constituted 20{\%} of the population, and a 1 mm perimeter in which 8{\%} of the cells responded to taste. Data were collected from three awake cynomolgus monkeys (Macaco fascicularis) prepared for chronic recording. Single neurons were isolated with epoxylite-coated tungsten microelectrodes and tested for responsiveness to 1.0 M glucose, 0.3 M NaCl, 0.03 M HCl, and 0.001 M QHCl. These stimuli elicited responses that were 96{\%} excitatory and ranged from 5.2 to 5.9 spikes/s. Cells were broadly tuned (H = 0.79), similar to those in the anterior insula (H = 0.70), and decidedly unlike the narrowly tuned taste neurons in the caudolateral OFC (clOFC; H = 0.39). Whereas 82{\%} of the taste cells in the clOFC respond to glucose, in the mOFC, HCl-responsive (56{\%}), glucose-responsive (50{\%}), NaCl-responsive (43{\%}), and QHCl-responsive (40{\%}) cells were almost evenly represented. The mOFC taste area appears to comprise a major gustatory relay that lies anatomically and functionally between the anterior insula and the clOFC.",
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