Gunn rat: a model for inherited deficiency of bilirubin glucuronidation.

Jayanta Roy-Chowdhury, R. Kondapalli, N. R. Chowdhury

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Experiments in Gunn rats have provided important insights into physiological, biochemical, and molecular mechanisms of bilirubin conjugation and disposition. The Gunn rat is a natural model for bilirubin encephalopathy, and much of our knowledge of bilirubin toxicity and its treatment has come from studies performed in Gunn rats. The genetic lesion in Gunn rats closely parallel those in Crigler-Najjar syndrome, Type I. Presently, the Gunn rat model is being used to develop methods for gene therapy for inherited bilirubin-UGT deficiency. Thus, Gunn rats continue to be a valuable model for the investigation of inherited UGT deficiency and severe nonhemolytic unconjugated hyperbilirubinemia.

Original languageEnglish (US)
Pages (from-to)149-173
Number of pages25
JournalAdvances in Veterinary Science and Comparative Medicine
Volume37
StatePublished - 1993

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Gunn Rats
bilirubin
Bilirubin
animal models
rats
hyperbilirubinemia
Crigler-Najjar Syndrome
encephalopathy
Kernicterus
gene therapy
Hyperbilirubinemia
Genetic Therapy
toxicity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gunn rat : a model for inherited deficiency of bilirubin glucuronidation. / Roy-Chowdhury, Jayanta; Kondapalli, R.; Chowdhury, N. R.

In: Advances in Veterinary Science and Comparative Medicine, Vol. 37, 1993, p. 149-173.

Research output: Contribution to journalArticle

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