Growth of murine sarcoma virus-transformed rat kidney cells in nude mice: Absence of induction of host endogenous viruses

John A. Bilello, Victoria H. Freedman, Seung Il Shin

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Abstract

Clonal isolates of the normal rat kidney cell line (NRK) transformed by a defective murine sarcoma virus (Kirsten strain) were injected into nude mice of BALB/c background to determine whether the growth of these cells as tumors was accompanied by the induction of host endogenous type C viruses. All the virus-transformed clones produced rapidly growing tumors in nude mice, but neither the induction of mouse endogenous viruses nor the rescue and spread of the transforming sarcoma virus were observed during the growth of tumors. The degree of expression of the tumor virus structural proteins in the transformed cells did not determine the cellular phenotype with regard to tumorigenicity in nude mice, nor did it modify the cellular growth properties in vitro. Consistent with earlier observations with simian virus 40-transformed mouse and rat cells, the ability of sarcoma virus-transformed NRK cells to initiate tumor growth in nude mice appeared to be correlated with anchorage-independent growth in vitro.

Original languageEnglish (US)
Pages (from-to)1691-1694
Number of pages4
JournalJournal of the National Cancer Institute
Volume58
Issue number6
DOIs
Publication statusPublished - Jun 1977

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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