Growth of Ectopic Dendrites on Cortical Pyramidal Neurons in Neuronal Storage Diseases Correlates with Abnormal Accumulation of GM2 Ganglioside

Donald A. Siegel, Steven U. Walkley

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Abstract: Ganglioside analysis and quantitative Golgi studies of the cerebral cortex of cats with ganglioside and nonganglioside lysosomal storage diseases reveal a correlation between the amount of accumulated GM2 ganglioside and the extent of ectopic dendrite growth on cortical pyramidal neurons. This correlation was not observed with any of the other gangliosides assayed for, including GM1 ganglioside. These results suggest a specific role for GM2 ganglioside in the initiation of ectopic neurites on pyramidal cells in vivo and are consistent with the developing hypothesis that different gangliosides have specific roles in different cell types dependent upon the receptor or other effector molecules with which they may interact.

Original languageEnglish (US)
Pages (from-to)1852-1862
Number of pages11
JournalJournal of Neurochemistry
Volume62
Issue number5
DOIs
Publication statusPublished - May 1994

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Keywords

  • Dendrite
  • Dendritic initiation
  • GM2 ganglioside
  • Gangliosides
  • Neuronal storage disease

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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