Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors

Carine Bécamel; Coralie Berthoux; Alexander Barre; Philippe Marin

doi:10.1021/acschemneuro.6b00409

Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors

Carine Bécamel, Coralie Berthoux, Alexander Barre, Philippe Marin

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The serotonin 2A (5-HT2A) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. 5-HT2A receptors are a principal G protein-coupled receptor subtype mediating the excitatory effects of serotonin. Nonetheless, pre- vs postsynaptic localization of 5HT2A receptors, relative to glutamatergic synapses, has remained controversial. Here, we discuss recent findings highlighting the existence and roles of presynaptic 5-HT2A receptors in regulating glutamatergic transmission and cognition.

Original language	English (US)
Pages (from-to)	897-899
Number of pages	3
Journal	ACS Chemical Neuroscience
Volume	8
Issue number	5
DOIs	https://doi.org/10.1021/acschemneuro.6b00409
State	Published - May 17 2017
Externally published	Yes

Keywords

5-HT2A receptor
heteroreceptor
presynaptic

ASJC Scopus subject areas

Biochemistry
Physiology
Cognitive Neuroscience
Cell Biology

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10.1021/acschemneuro.6b00409

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title = "Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors",

abstract = "The serotonin 2A (5-HT2A) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. 5-HT2A receptors are a principal G protein-coupled receptor subtype mediating the excitatory effects of serotonin. Nonetheless, pre- vs postsynaptic localization of 5HT2A receptors, relative to glutamatergic synapses, has remained controversial. Here, we discuss recent findings highlighting the existence and roles of presynaptic 5-HT2A receptors in regulating glutamatergic transmission and cognition.",

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AU - Bécamel, Carine

AU - Berthoux, Coralie

AU - Barre, Alexander

AU - Marin, Philippe

PY - 2017/5/17

Y1 - 2017/5/17

N2 - The serotonin 2A (5-HT2A) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. 5-HT2A receptors are a principal G protein-coupled receptor subtype mediating the excitatory effects of serotonin. Nonetheless, pre- vs postsynaptic localization of 5HT2A receptors, relative to glutamatergic synapses, has remained controversial. Here, we discuss recent findings highlighting the existence and roles of presynaptic 5-HT2A receptors in regulating glutamatergic transmission and cognition.

AB - The serotonin 2A (5-HT2A) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. 5-HT2A receptors are a principal G protein-coupled receptor subtype mediating the excitatory effects of serotonin. Nonetheless, pre- vs postsynaptic localization of 5HT2A receptors, relative to glutamatergic synapses, has remained controversial. Here, we discuss recent findings highlighting the existence and roles of presynaptic 5-HT2A receptors in regulating glutamatergic transmission and cognition.

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KW - heteroreceptor

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Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors

Abstract

Keywords

ASJC Scopus subject areas

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