Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors

Carine Bécamel, Coralie Berthoux, Alexander Barre, Philippe Marin

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

The serotonin 2A (5-HT2A) receptor subtype continues to attract attention as a target for numerous psychoactive drugs including psychedelic hallucinogens, antidepressants, anxiolytics, and atypical antipsychotics. 5-HT2A receptors are a principal G protein-coupled receptor subtype mediating the excitatory effects of serotonin. Nonetheless, pre- vs postsynaptic localization of 5HT2A receptors, relative to glutamatergic synapses, has remained controversial. Here, we discuss recent findings highlighting the existence and roles of presynaptic 5-HT2A receptors in regulating glutamatergic transmission and cognition.

Original languageEnglish (US)
Pages (from-to)897-899
Number of pages3
JournalACS Chemical Neuroscience
Volume8
Issue number5
DOIs
StatePublished - May 17 2017
Externally publishedYes

Keywords

  • 5-HT2A receptor
  • heteroreceptor
  • presynaptic

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

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