Group I metabotropic glutamate receptor interacting proteins: Fine-tuning receptor functions in health and disease

Magdalena Kalinowska, Anna Francesconi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Group I metabotropic glutamate receptors mediate slow excitatory neurotransmission in the central nervous system and are critical to activity-dependent synaptic plasticity, a cellular substrate of learning and memory. Dysregulated receptor signaling is implicated in neuropsychiatric conditions ranging from neurodevelopmental to neurodegenerative disorders. Importantly, group I metabotropic glutamate receptor signaling functions can be modulated by interacting proteins that mediate receptor trafficking, expression and coupling efficiency to signaling effectors. These interactions afford cell-or pathway-specific modulation to fine-tune receptor function, thus representing a potential target for pharmacological interventions in pathological conditions.

Original languageEnglish (US)
Pages (from-to)494-503
Number of pages10
JournalCurrent Neuropharmacology
Volume14
Issue number5
DOIs
StatePublished - Jul 1 2016

Keywords

  • Amyloid-β
  • CaMKII α
  • Caveolin-1
  • Homer
  • Norbin
  • PrP
  • Synaptic plasticity
  • mGluR

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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