Group I metabotropic glutamate receptor interacting proteins: Fine-tuning receptor functions in health and disease

Magdalena Kalinowska, Anna Francesconi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Group I metabotropic glutamate receptors mediate slow excitatory neurotransmission in the central nervous system and are critical to activity-dependent synaptic plasticity, a cellular substrate of learning and memory. Dysregulated receptor signaling is implicated in neuropsychiatric conditions ranging from neurodevelopmental to neurodegenerative disorders. Importantly, group I metabotropic glutamate receptor signaling functions can be modulated by interacting proteins that mediate receptor trafficking, expression and coupling efficiency to signaling effectors. These interactions afford cell-or pathway-specific modulation to fine-tune receptor function, thus representing a potential target for pharmacological interventions in pathological conditions.

Original languageEnglish (US)
Pages (from-to)494-503
Number of pages10
JournalCurrent Neuropharmacology
Volume14
Issue number5
StatePublished - Jul 1 2016

Fingerprint

Receptor-Interacting Protein Serine-Threonine Kinases
Metabotropic Glutamate Receptors
Neuronal Plasticity
Health
Cell Communication
Synaptic Transmission
Neurodegenerative Diseases
Central Nervous System
Learning
Pharmacology
Efficiency

Keywords

  • Amyloid-β
  • CaMKII α
  • Caveolin-1
  • Homer
  • mGluR
  • Norbin
  • PrP
  • Synaptic plasticity

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health

Cite this

Group I metabotropic glutamate receptor interacting proteins : Fine-tuning receptor functions in health and disease. / Kalinowska, Magdalena; Francesconi, Anna.

In: Current Neuropharmacology, Vol. 14, No. 5, 01.07.2016, p. 494-503.

Research output: Contribution to journalArticle

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