Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors

Jingqi Yan, Yan Zhao, Bao Lu Zhao

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the anti-obesity mechanisms of green tea catechins (GTCs) through modulation of peroxisome proliferator activated-receptor (PPAR) pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels. Meanwhile, GTCs increased the PPARγ levels in subcutaneous white adipose tissue (SWAT) and decreased the PPARγ levels in visceral white adipose tissue (VWAT). In addition, GTC treatment up-regulated the levels of PPARδ in SWAT, VWAT, and brown adipose tissue and increased the expression of genes involved in fatty acid oxidation in brown adipose tissue. Our results suggest that GTCs exert their anti-obesity mechanism in part by modulating PPAR signaling pathways.

Original languageEnglish (US)
Pages (from-to)804-810
Number of pages7
JournalScience China Life Sciences
Volume56
Issue number9
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Fingerprint

Peroxisome Proliferator-Activated Receptors
obesity
Catechin
tea
green tea
Tea
flavanols
White Adipose Tissue
white adipose tissue
Obesity
Modulation
Tissue
Brown Adipose Tissue
brown adipose tissue
Intra-Abdominal Fat
Subcutaneous Fat
Liver
liver
beta oxidation
High Fat Diet

Keywords

  • green tea catechins
  • hyperlipidemia
  • metabolic syndrome
  • obesity
  • peroxisome proliferator activated-receptors (PPARs)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors. / Yan, Jingqi; Zhao, Yan; Zhao, Bao Lu.

In: Science China Life Sciences, Vol. 56, No. 9, 01.09.2013, p. 804-810.

Research output: Contribution to journalArticle

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N2 - Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the anti-obesity mechanisms of green tea catechins (GTCs) through modulation of peroxisome proliferator activated-receptor (PPAR) pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels. Meanwhile, GTCs increased the PPARγ levels in subcutaneous white adipose tissue (SWAT) and decreased the PPARγ levels in visceral white adipose tissue (VWAT). In addition, GTC treatment up-regulated the levels of PPARδ in SWAT, VWAT, and brown adipose tissue and increased the expression of genes involved in fatty acid oxidation in brown adipose tissue. Our results suggest that GTCs exert their anti-obesity mechanism in part by modulating PPAR signaling pathways.

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