Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress

Jingqi Yan, Yan Zhao, Siqingaowa Suo, Yang Liu, Baolu Zhao

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Epidemiological data have suggested that drinking green tea is negatively associated with diabetes, and adipose oxidative stress may have a central role in causing insulin resistance, according to recent findings. The aim of this work is to elucidate a new mechanism for green tea's anti-insulin resistance effect. We used obese KK-ay mice, high-fat diet-induced obese rats, and induced insulin resistant 3T3-L1 adipocytes as models. Insulin sensitivity and adipose reactive oxidative species (ROS) levels were detected in animals and adipocytes. The oxidative stress assay and glucose uptake ability assay were performed, and the effects of EGCG on insulin signals were detected. Green tea catechins (GTCs) significantly decreased glucose levels and increased glucose tolerance in animals. GTCs reduced ROS content in both models of animal and adipocytes. EGCG attenuated dexamethasone and TNF-α promoted ROS generation and increased glucose uptake ability. EGCG also decreased JNK phosphorylation and promoted GLUT-4 translocation. EGCG and GTCs could improve adipose insulin resistance, and exact this effect on their ROS scavenging functions.

Original languageEnglish (US)
Pages (from-to)1648-1657
Number of pages10
JournalFree Radical Biology and Medicine
Volume52
Issue number9
DOIs
StatePublished - May 1 2012
Externally publishedYes

Keywords

  • Adipocyte
  • Diabetes
  • EGCG
  • Green tea catechins
  • Insulin resistance
  • Reactive oxidative species (ROS)

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress'. Together they form a unique fingerprint.

  • Cite this