Green fluorescent proteins are light-induced electron donors

Alexey M. Bogdanov, Alexander S. Mishin, Ilia V. Yampolsky, Vsevolod V. Belousov, Dmitriy M. Chudakov, Fedor V. Subach, Vladislav V. Verkhusha, Sergey Lukyanov, Konstantin A. Lukyanov

Research output: Contribution to journalArticle

132 Scopus citations

Abstract

Proteins of the green fluorescent protein (GFP) family are well known owing to their unique biochemistry and extensive use as in vivo markers. We discovered that GFPs of diverse origins can act as light-induced electron donors in photochemical reactions with various electron acceptors, including biologically relevant ones. Moreover, via green-to-red GFP photoconversion, this process can be observed in living cells without additional treatment.

Original languageEnglish (US)
Pages (from-to)459-461
Number of pages3
JournalNature Chemical Biology
Volume5
Issue number7
DOIs
StatePublished - Jul 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Bogdanov, A. M., Mishin, A. S., Yampolsky, I. V., Belousov, V. V., Chudakov, D. M., Subach, F. V., Verkhusha, V. V., Lukyanov, S., & Lukyanov, K. A. (2009). Green fluorescent proteins are light-induced electron donors. Nature Chemical Biology, 5(7), 459-461. https://doi.org/10.1038/nchembio.174