Abstract
Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how they relate to specific cognitive domains, are not well-understood. We examined structural brain correlates of gait speed, and how they relate to processing speed, executive function, and episodic memory in three non-demented and community-dwelling older adult cohorts (Overall N = 352), using voxel-based morphometry and multivariate covariance-based statistics. In all three cohorts, we identified gray matter volume covariance patterns associated with gait speed that included brain stem, precuneus, fusiform, motor, supplementary motor, and prefrontal (particularly ventrolateral prefrontal) cortex regions. Greater expression of these gray matter volume covariance patterns linked to gait speed were associated with better processing speed in all three cohorts, and with better executive function in one cohort. These gray matter covariance patterns linked to gait speed were not associated with episodic memory in any of the cohorts. These findings suggest that gait speed, processing speed (and to some extent executive functions) rely on shared neural systems that are subject to age-related and dementia-related change. The implications of these findings are discussed within the context of the development of interventions to compensate for age-related gait and cognitive decline.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-15 |
| Number of pages | 15 |
| Journal | Brain Imaging and Behavior |
| DOIs | |
| State | Accepted/In press - Apr 9 2018 |
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Keywords
- Cognition
- Gait
- Gray matter
- Magnetic resonance imaging
- Multivariate analyses
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Neurology
- Cognitive Neuroscience
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
- Behavioral Neuroscience
Cite this
Gray matter volume covariance patterns associated with gait speed in older adults : a multi-cohort MRI study. / Blumen, Helena M.; Brown, Lucy L.; Habeck, Christian; Allali, Gilles; Ayers, Emmeline I.; Beauchet, Olivier; Callisaya, Michele; Lipton, Richard B.; Mathuranath, P. S.; Phan, Thanh G.; Pradeep Kumar, V. G.; Srikanth, Velandai; Verghese, Joe.
In: Brain Imaging and Behavior, 09.04.2018, p. 1-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gray matter volume covariance patterns associated with gait speed in older adults
T2 - a multi-cohort MRI study
AU - Blumen, Helena M.
AU - Brown, Lucy L.
AU - Habeck, Christian
AU - Allali, Gilles
AU - Ayers, Emmeline I.
AU - Beauchet, Olivier
AU - Callisaya, Michele
AU - Lipton, Richard B.
AU - Mathuranath, P. S.
AU - Phan, Thanh G.
AU - Pradeep Kumar, V. G.
AU - Srikanth, Velandai
AU - Verghese, Joe
PY - 2018/4/9
Y1 - 2018/4/9
N2 - Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how they relate to specific cognitive domains, are not well-understood. We examined structural brain correlates of gait speed, and how they relate to processing speed, executive function, and episodic memory in three non-demented and community-dwelling older adult cohorts (Overall N = 352), using voxel-based morphometry and multivariate covariance-based statistics. In all three cohorts, we identified gray matter volume covariance patterns associated with gait speed that included brain stem, precuneus, fusiform, motor, supplementary motor, and prefrontal (particularly ventrolateral prefrontal) cortex regions. Greater expression of these gray matter volume covariance patterns linked to gait speed were associated with better processing speed in all three cohorts, and with better executive function in one cohort. These gray matter covariance patterns linked to gait speed were not associated with episodic memory in any of the cohorts. These findings suggest that gait speed, processing speed (and to some extent executive functions) rely on shared neural systems that are subject to age-related and dementia-related change. The implications of these findings are discussed within the context of the development of interventions to compensate for age-related gait and cognitive decline.
AB - Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how they relate to specific cognitive domains, are not well-understood. We examined structural brain correlates of gait speed, and how they relate to processing speed, executive function, and episodic memory in three non-demented and community-dwelling older adult cohorts (Overall N = 352), using voxel-based morphometry and multivariate covariance-based statistics. In all three cohorts, we identified gray matter volume covariance patterns associated with gait speed that included brain stem, precuneus, fusiform, motor, supplementary motor, and prefrontal (particularly ventrolateral prefrontal) cortex regions. Greater expression of these gray matter volume covariance patterns linked to gait speed were associated with better processing speed in all three cohorts, and with better executive function in one cohort. These gray matter covariance patterns linked to gait speed were not associated with episodic memory in any of the cohorts. These findings suggest that gait speed, processing speed (and to some extent executive functions) rely on shared neural systems that are subject to age-related and dementia-related change. The implications of these findings are discussed within the context of the development of interventions to compensate for age-related gait and cognitive decline.
KW - Cognition
KW - Gait
KW - Gray matter
KW - Magnetic resonance imaging
KW - Multivariate analyses
UR - http://www.scopus.com/inward/record.url?scp=85045112149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045112149&partnerID=8YFLogxK
U2 - 10.1007/s11682-018-9871-7
DO - 10.1007/s11682-018-9871-7
M3 - Article
C2 - 29629501
AN - SCOPUS:85045112149
SP - 1
EP - 15
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
ER -