Gray matter volume and dual-task gait performance in mild cognitive impairment

Takehiko Doi, Helena M. Blumen, Joe Verghese, Hiroyuki Shimada, Hyuma Makizako, Kota Tsutsumimoto, Ryo Hotta, Sho Nakakubo, Takao Suzuki

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Dual-task gait performance is impaired in older adults with mild cognitive impairment, but the brain substrates associated with dual-task gait performance are not well-established. The relationship between gray matter and gait speed under single-task and dual-task conditions (walking while counting backward) was examined in 560 seniors with mild cognitive impairment (non-amnestic mild cognitive impairment: n = 270; mean age = 72.4 yrs., 63.6 % women; amnestic mild cognitive impairment: n = 290; mean age = 73.4 yrs., 45.4 % women). Multivariate covariance-based analyses of magnetic resonance imaging data, adjusted for potential confounders including single-task gait speed, were performed to identify gray matter patterns associated with dual-task gait speed. There were no differences in gait speed or cognitive performance during dual-task gait between individuals with non-amnestic mild cognitive impairment and amnestic mild cognitive impairment. Overall, increased dual-task gait speed was associated with a gray matter pattern of increased volume in medial frontal gyrus, superior frontal gyrus, anterior cingulate, cingulate, precuneus, fusiform gyrus, middle occipital gyrus, inferior temporal gyrus and middle temporal gyrus. The relationship between dual-task gait speed and brain substrates also differed by mild cognitive impairment subtype. Our study revealed a pattern of gray matter regions associated with dual-task performance. Although dual-task gait performance was similar in amnestic and non-amnestic mild cognitive impairment, the gray matter patterns associated with dual-task gait performance differed by mild cognitive impairment subtype. These findings suggest that the brain substrates supporting dual-task gait performance in amnestic and non-amnestic subtypes are different, and consequently may respond differently to interventions, or require different interventions.

Original languageEnglish (US)
Pages (from-to)887-898
Number of pages12
JournalBrain Imaging and Behavior
Volume11
Issue number3
DOIs
StatePublished - Jun 1 2017

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Keywords

  • Brain atrophy
  • Dementia
  • MCI
  • Mobility

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Doi, T., Blumen, H. M., Verghese, J., Shimada, H., Makizako, H., Tsutsumimoto, K., Hotta, R., Nakakubo, S., & Suzuki, T. (2017). Gray matter volume and dual-task gait performance in mild cognitive impairment. Brain Imaging and Behavior, 11(3), 887-898. https://doi.org/10.1007/s11682-016-9562-1