Graves' disease presenting with severe cholestasis

Molly O. Regelmann, Tamir Miloh, Ronen Arnon, Raffaella Morotti, Nanda Kerkar, Robert Rapaport

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Hyperthyroidism has been associated with liver function abnormalities; however, cholestasis as the presenting feature of adolescent Graves' disease has not been previously reported. Patient Summary: The patient was a 17-year-old girl who presented with severe cholestasis and was found to have Graves' disease. She also had a positive hepatitis A immunoglobulin M antibody but her clinical course, the liver histopathology, and her mildly elevated transaminases indicated that the acute hepatitis A infection was not dominant at the time of presentation with severe cholestasis. Other causes of cholestasis, including congestive heart failure, autoimmune hepatitis, and viral infection, were excluded. Treatment with methimazole resolved the hyperthyroidism, and the cholestasis improved, as well. Conclusion: Severe cholestasis is a rare presenting feature of Graves' disease. With careful monitoring, methimazole can be used to treat the hyperthyroidism in the setting of cholestasis.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalThyroid
Volume22
Issue number4
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Fingerprint

Graves Disease
Cholestasis
Hyperthyroidism
Methimazole
Hepatitis A
Autoimmune Hepatitis
Liver
Virus Diseases
Transaminases
Immunoglobulin M
Heart Failure
Antibodies
Infection

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Regelmann, M. O., Miloh, T., Arnon, R., Morotti, R., Kerkar, N., & Rapaport, R. (2012). Graves' disease presenting with severe cholestasis. Thyroid, 22(4), 437-439. https://doi.org/10.1089/thy.2011.0267

Graves' disease presenting with severe cholestasis. / Regelmann, Molly O.; Miloh, Tamir; Arnon, Ronen; Morotti, Raffaella; Kerkar, Nanda; Rapaport, Robert.

In: Thyroid, Vol. 22, No. 4, 01.04.2012, p. 437-439.

Research output: Contribution to journalArticle

Regelmann, MO, Miloh, T, Arnon, R, Morotti, R, Kerkar, N & Rapaport, R 2012, 'Graves' disease presenting with severe cholestasis', Thyroid, vol. 22, no. 4, pp. 437-439. https://doi.org/10.1089/thy.2011.0267
Regelmann MO, Miloh T, Arnon R, Morotti R, Kerkar N, Rapaport R. Graves' disease presenting with severe cholestasis. Thyroid. 2012 Apr 1;22(4):437-439. https://doi.org/10.1089/thy.2011.0267
Regelmann, Molly O. ; Miloh, Tamir ; Arnon, Ronen ; Morotti, Raffaella ; Kerkar, Nanda ; Rapaport, Robert. / Graves' disease presenting with severe cholestasis. In: Thyroid. 2012 ; Vol. 22, No. 4. pp. 437-439.
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