TY - JOUR
T1 - Graves' disease presenting with severe cholestasis
AU - Regelmann, Molly O.
AU - Miloh, Tamir
AU - Arnon, Ronen
AU - Morotti, Raffaella
AU - Kerkar, Nanda
AU - Rapaport, Robert
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Background: Hyperthyroidism has been associated with liver function abnormalities; however, cholestasis as the presenting feature of adolescent Graves' disease has not been previously reported. Patient Summary: The patient was a 17-year-old girl who presented with severe cholestasis and was found to have Graves' disease. She also had a positive hepatitis A immunoglobulin M antibody but her clinical course, the liver histopathology, and her mildly elevated transaminases indicated that the acute hepatitis A infection was not dominant at the time of presentation with severe cholestasis. Other causes of cholestasis, including congestive heart failure, autoimmune hepatitis, and viral infection, were excluded. Treatment with methimazole resolved the hyperthyroidism, and the cholestasis improved, as well. Conclusion: Severe cholestasis is a rare presenting feature of Graves' disease. With careful monitoring, methimazole can be used to treat the hyperthyroidism in the setting of cholestasis.
AB - Background: Hyperthyroidism has been associated with liver function abnormalities; however, cholestasis as the presenting feature of adolescent Graves' disease has not been previously reported. Patient Summary: The patient was a 17-year-old girl who presented with severe cholestasis and was found to have Graves' disease. She also had a positive hepatitis A immunoglobulin M antibody but her clinical course, the liver histopathology, and her mildly elevated transaminases indicated that the acute hepatitis A infection was not dominant at the time of presentation with severe cholestasis. Other causes of cholestasis, including congestive heart failure, autoimmune hepatitis, and viral infection, were excluded. Treatment with methimazole resolved the hyperthyroidism, and the cholestasis improved, as well. Conclusion: Severe cholestasis is a rare presenting feature of Graves' disease. With careful monitoring, methimazole can be used to treat the hyperthyroidism in the setting of cholestasis.
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U2 - 10.1089/thy.2011.0267
DO - 10.1089/thy.2011.0267
M3 - Article
C2 - 22458973
AN - SCOPUS:84859336555
SN - 1050-7256
VL - 22
SP - 437
EP - 439
JO - Thyroid
JF - Thyroid
IS - 4
ER -