Graves' disease and autoimmune factor VIII deficiency

Rubens Sievert, Mervyn L. Goldstein, Martin I. Surks

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A patient with longstanding Hashimoto's thyroiditis who was treated with L-thyroxine at a dosage of 0.05 mg/day developed a decreased serum TSH concentration. L-Thyroxine was discontinued. Within 1 month, the patient developed mild hyperthyroidism due to Graves' disease. A hemorrhagic disorder occurred simultaneously with bleeding into muscle, joints, and skin. The bleeding disorder was identified as an acquired factor VIII deficiency due to a factor VIII inhibitor. The bleeding disorder resolved after treatment with prednisone, cyclophosphamide, and intravenous gamma globulin. Graves' disease also resolved but without specific treatment with either antithyroid drugs or radioactive iodine. The development of these two autoimmune disorders in this patient simultaneously suggests an underlying derangement in immune regulation common to both diseases.

Original languageEnglish (US)
Pages (from-to)245-247
Number of pages3
JournalThyroid
Volume6
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

Graves Disease
Hemophilia A
Hemorrhage
Thyroxine
Hemorrhagic Disorders
Antithyroid Agents
Hashimoto Disease
gamma-Globulins
Factor VIII
Hyperthyroidism
Prednisone
Iodine
Cyclophosphamide
Joints
Muscles
Skin
Therapeutics
Serum

ASJC Scopus subject areas

  • Endocrinology

Cite this

Sievert, R., Goldstein, M. L., & Surks, M. I. (1996). Graves' disease and autoimmune factor VIII deficiency. Thyroid, 6(3), 245-247.

Graves' disease and autoimmune factor VIII deficiency. / Sievert, Rubens; Goldstein, Mervyn L.; Surks, Martin I.

In: Thyroid, Vol. 6, No. 3, 1996, p. 245-247.

Research output: Contribution to journalArticle

Sievert, R, Goldstein, ML & Surks, MI 1996, 'Graves' disease and autoimmune factor VIII deficiency', Thyroid, vol. 6, no. 3, pp. 245-247.
Sievert R, Goldstein ML, Surks MI. Graves' disease and autoimmune factor VIII deficiency. Thyroid. 1996;6(3):245-247.
Sievert, Rubens ; Goldstein, Mervyn L. ; Surks, Martin I. / Graves' disease and autoimmune factor VIII deficiency. In: Thyroid. 1996 ; Vol. 6, No. 3. pp. 245-247.
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