Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation

Fabio Re, Svetlana L. Belyanskaya, Richiard J. Riese, Barbara Cipriani, Falko R. Fischer, Francesca Granucci, Paola Ricciardi-Castagnoli, Celia Brosnan, Lawrence J. Stern, Jack L. Strominger, Laura Santambrogio

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Neonatal microglial cells respond to GM-CSF and M-CSF by acquiring different morphologies and phenotypes. To investigate the extent and consequences of this process, a global gene expression analysis was performed, with significant changes in transcript levels confirmed by biochemical analyses. Primary murine microglial cells underwent substantial expression reprogramming after treatment with GM-CSF or M-CSF with many differentially expressed transcripts important in innate and adaptive immunity. In particular, many gene products involved in Ag presentation were induced by GM-CSF, but not M-CSF, thus potentially priming relatively quiescent microglia cells for Ag presentation. This function of GM-CSF is distinct from its primary function in cell proliferation and survival.

Original languageEnglish (US)
Pages (from-to)2264-2273
Number of pages10
JournalJournal of Immunology
Volume169
Issue number5
StatePublished - Sep 1 2002
Externally publishedYes

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Macrophage Colony-Stimulating Factor
Antigen Presentation
Microglia
Granulocyte-Macrophage Colony-Stimulating Factor
Adaptive Immunity
Innate Immunity
Cell Survival
Cell Proliferation
Phenotype
Gene Expression
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Re, F., Belyanskaya, S. L., Riese, R. J., Cipriani, B., Fischer, F. R., Granucci, F., ... Santambrogio, L. (2002). Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. Journal of Immunology, 169(5), 2264-2273.

Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. / Re, Fabio; Belyanskaya, Svetlana L.; Riese, Richiard J.; Cipriani, Barbara; Fischer, Falko R.; Granucci, Francesca; Ricciardi-Castagnoli, Paola; Brosnan, Celia; Stern, Lawrence J.; Strominger, Jack L.; Santambrogio, Laura.

In: Journal of Immunology, Vol. 169, No. 5, 01.09.2002, p. 2264-2273.

Research output: Contribution to journalArticle

Re, F, Belyanskaya, SL, Riese, RJ, Cipriani, B, Fischer, FR, Granucci, F, Ricciardi-Castagnoli, P, Brosnan, C, Stern, LJ, Strominger, JL & Santambrogio, L 2002, 'Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation', Journal of Immunology, vol. 169, no. 5, pp. 2264-2273.
Re, Fabio ; Belyanskaya, Svetlana L. ; Riese, Richiard J. ; Cipriani, Barbara ; Fischer, Falko R. ; Granucci, Francesca ; Ricciardi-Castagnoli, Paola ; Brosnan, Celia ; Stern, Lawrence J. ; Strominger, Jack L. ; Santambrogio, Laura. / Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. In: Journal of Immunology. 2002 ; Vol. 169, No. 5. pp. 2264-2273.
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